An N-terminal cysteine is used to displace bromide from a bromoacetylated porphyrin to yield a thioether linkage between the peptide and the template. Unlike amide coupling reactions, this approach should be compatible with any peptide sequence provided there is only a single cysteine.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 22 1994|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry