A general method for coupling unprotected peptides to bromoacetamido porphyrin templates

Christin T. Choma, Karen Kaestle, Karin S. Åkerfeldt, Ronald M. Kim, John Taylor Groves, William F. DeGrado

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

An N-terminal cysteine is used to displace bromide from a bromoacetylated porphyrin to yield a thioether linkage between the peptide and the template. Unlike amide coupling reactions, this approach should be compatible with any peptide sequence provided there is only a single cysteine.

Original languageEnglish (US)
Pages (from-to)6191-6194
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number34
DOIs
StatePublished - Aug 22 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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