A general approach to the enantioselective α-oxidation of aldehydes via synergistic catalysis

Scott P. Simonovich, Jeffrey F. Van Humbeck, David W.C. MacMillan

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.

Original languageEnglish (US)
Pages (from-to)58-61
Number of pages4
JournalChemical Science
Volume3
Issue number1
DOIs
StatePublished - Jan 2012

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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