A general [3 + 2 + 1] annulation strategy for the preparation of pyridine N-oxides

Ian W. Davies, Jean François Marcoux, Paul J. Reider

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

equation presented Stabilized ketone, aldehyde, and ester enolates react with vinamidinium hexafluorophosphate salts and hydroxylamine hydrochloride to give access to the corresponding pyridine N-oxides. The annulation reactions proceed in good to excellent yields with vinamidinium salts with a range of β-substituents (R3 = halo, aryl, nitro, trifluoromethyl).

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalOrganic Letters
Volume3
Issue number2
DOIs
StatePublished - Jan 25 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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