Investigation into the selectivity observed in the synthesis of 1β-methylcarbapenems was carried out by examining (1) the rotational barrier between the two possible ketene acetal conformations A and B and (2) the protonation of ketene acetal 3 to the mono acid product 2, using the MNDO Hamiltonian.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Organic Chemistry|
|State||Published - Jul 1 1994|
All Science Journal Classification (ASJC) codes
- Organic Chemistry