A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

Keyphrases

• Tumor Growth 100%
• Glucocorticoid Receptor 100%
• Non-small Cell Lung Cancer (NSCLC) 100%
• Forkhead Box A1 (FOXA1) 100%
• Druggability 100%
• EGF Signaling 16%
• Glucocorticoid Receptor Antagonism 16%
• Growth Programs 16%
• Mass Spectrometry 8%
• Receptor Function 8%
• Highly Selective 8%
• Sigma Phase 8%
• Co-immunoprecipitation (co-IP) 8%
• Attendants 8%
• Tumor Cells 8%
• Therapeutic Targeting 8%
• Cell Cycle Progression 8%
• Therapeutic Potential 8%
• Estrogen Receptor 8%
• Chromatin 8%
• Lineage-specific 8%
• Knockdown 8%
• Steroid Receptors 8%
• Breast Cancer 8%
• Cancer Mortality 8%
• Gene Targeting 8%
• Cancer Causes 8%
• Targeted Expression 8%
• Endogenous Protein 8%
• Selective Inhibitor 8%
• Proliferation in Vitro 8%
• Prostate Cancer 8%
• Nuclear Receptor 8%
• Receptor Targets 8%
• Lung Tumor 8%
• Specific Growth 8%
• Androgen Receptor 8%
• Loss-of-function Screen 8%
• Pioneer Factor 8%
• SCell 8%
• Non-small Cell Lung Cancer Cells 8%
• Hormone-dependent Cancer 8%
• Localized Interaction 8%
• Estrogen/androgen 8%

Biochemistry, Genetics and Molecular Biology

• Tumor Progression 100%
• FOXA1 100%
• Glucocorticoid Receptor 100%
• Mass Spectrometry 8%
• S Phase 8%
• Immunoprecipitation 8%
• Cancer Cell 8%
• Mediator 8%
• Cell Cycle Progression 8%
• Cancer Mortality 8%
• Steroid Receptor 8%
• Estrogen Receptor 8%
• Nuclear Receptor 8%
• Chromatin 8%
• Androgen Receptor 8%
• Pioneer Factor 8%
• S Cell 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Tumor Growth 100%
• Non Small Cell Lung Cancer 100%
• Glucocorticoid Receptor 100%
• Neoplasm 20%
• Breast Cancer 10%
• Immunoprecipitation 10%
• Prostate Cancer 10%
• Steroid Receptor 10%
• Cell Nucleus Receptor 10%
• Cancer Mortality 10%
• Estrogen Receptor 10%
• Androgen Receptor 10%