Abstract
Equation presented The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing matathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.
Original language | English (US) |
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Pages (from-to) | 671-674 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - Mar 8 2001 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry