A depression network of functionally connected regions discovered via multi-attribute canonical correlation graphs

Jian Kang, F. Du Bois Bowman, Helen Mayberg, Han Liu

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

To establish brain network properties associated with major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (Rs-fMRI) data, we develop a multi-attribute graph model to construct a region-level functional connectivity network that uses all voxel level information. For each region pair, we define the strength of the connectivity as the kernel canonical correlation coefficient between voxels in the two regions; and we develop a permutation test to assess the statistical significance. We also construct a network based classifier for making predictions on the risk of MDD. We apply our method to Rs-fMRI data from 20 MDD patients and 20 healthy control subjects in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study. Using this method, MDD patients can be distinguished from healthy control subjects based on significant differences in the strength of regional connectivity. We also demonstrate the performance of the proposed method using simulationstudies.

Original languageEnglish (US)
Pages (from-to)431-441
Number of pages11
JournalNeuroimage
Volume141
DOIs
StatePublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

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