A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429

M. Bhupathy, J. J. Bergan, J. M. McNamara, R. P. Volante, P. J. Reider

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.

Original languageEnglish (US)
Pages (from-to)9445-9448
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number52
DOIs
StatePublished - Dec 25 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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