A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429

M. Bhupathy; J. J. Bergan; J. M. McNamara; R. P. Volante; P. J. Reider

doi:10.1016/0040-4039(95)02033-0

A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429

M. Bhupathy, J. J. Bergan, J. M. McNamara, R. P. Volante, P. J. Reider

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.

Original language	English (US)
Pages (from-to)	9445-9448
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	52
DOIs	https://doi.org/10.1016/0040-4039(95)02033-0
State	Published - Dec 25 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(95)02033-0

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title = "A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429",

abstract = "A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.",

author = "M. Bhupathy and Bergan, {J. J.} and McNamara, {J. M.} and Volante, {R. P.} and Reider, {P. J.}",

year = "1995",

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AU - Bhupathy, M.

AU - Bergan, J. J.

AU - McNamara, J. M.

AU - Volante, R. P.

AU - Reider, P. J.

PY - 1995/12/25

Y1 - 1995/12/25

N2 - A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.

AB - A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429

Abstract

All Science Journal Classification (ASJC) codes

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