A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Rasika Ann Mathias; Margaret A. Taub; Christopher R. Gignoux; Wenqing Fu; Shaila Musharoff; Timothy D. O'Connor; Candelaria Vergara; Dara G. Torgerson; Maria Pino-Yanes; Suyash S. Shringarpure; Lili Huang; Nicholas Rafaels; Meher Preethi Boorgula; Henry Richard Johnston; Victor E. Ortega; Albert M. Levin; Wei Song; Raul Torres; Badri Padhukasahasram; Celeste Eng; Delmy Aracely Mejia-Mejia; Trevor Ferguson; Zhaohui S. Qin; Alan F. Scott; Maria Yazdanbakhsh; James G. Wilson; Javier Marrugo; Leslie A. Lange; Rajesh Kumar; Pedro C. Avila; L. Keoki Williams; Harold Watson; Lorraine B. Ware; Christopher Olopade; Olufunmilayo Olopade; Ricardo Oliveira; Carole Ober; Dan L. Nicolae; Deborah Meyers; Alvaro Mayorga; Jennifer Knight-Madden; Tina Hartert; Nadia N. Hansel; Marilyn G. Foreman; Jean G. Ford; Mezbah U. Faruque; Georgia M. Dunston; Luis Caraballo; Esteban G. Burchard; Eugene Bleecker; Maria Ilma Araujo; Edwin Francisco Herrera-Paz; Kimberly Gietzen; Wendy E. Grus; Michael Bamshad; Carlos D. Bustamante; Eimear E. Kenny; Ryan D. Hernandez; Terri H. Beaty; Ingo Ruczinski; Joshua Akey; Kathleen C. Barnes

doi:10.1038/ncomms12522

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Rasika Ann Mathias, Margaret A. Taub, Christopher R. Gignoux, Wenqing Fu, Shaila Musharoff, Timothy D. O'Connor, Candelaria Vergara, Dara G. Torgerson, Maria Pino-Yanes, Suyash S. Shringarpure, Lili Huang, Nicholas Rafaels, Meher Preethi Boorgula, Henry Richard Johnston, Victor E. Ortega, Albert M. Levin, Wei Song, Raul Torres, Badri Padhukasahasram, Celeste EngDelmy Aracely Mejia-Mejia, Trevor Ferguson, Zhaohui S. Qin, Alan F. Scott, Maria Yazdanbakhsh, James G. Wilson, Javier Marrugo, Leslie A. Lange, Rajesh Kumar, Pedro C. Avila, L. Keoki Williams, Harold Watson, Lorraine B. Ware, Christopher Olopade, Olufunmilayo Olopade, Ricardo Oliveira, Carole Ober, Dan L. Nicolae, Deborah Meyers, Alvaro Mayorga, Jennifer Knight-Madden, Tina Hartert, Nadia N. Hansel, Marilyn G. Foreman, Jean G. Ford, Mezbah U. Faruque, Georgia M. Dunston, Luis Caraballo, Esteban G. Burchard, Eugene Bleecker, Maria Ilma Araujo, Edwin Francisco Herrera-Paz, Kimberly Gietzen, Wendy E. Grus, Michael Bamshad, Carlos D. Bustamante, Eimear E. Kenny, Ryan D. Hernandez, Terri H. Beaty, Ingo Ruczinski, Joshua Akey, Kathleen C. Barnes

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

Original language	English (US)
Article number	12522
Journal	Nature communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms12522
State	Published - Oct 11 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/ncomms12522

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Mathias, R. A., Taub, M. A., Gignoux, C. R., Fu, W., Musharoff, S., O'Connor, T. D., Vergara, C., Torgerson, D. G., Pino-Yanes, M., Shringarpure, S. S., Huang, L., Rafaels, N., Boorgula, M. P., Johnston, H. R., Ortega, V. E., Levin, A. M., Song, W., Torres, R., Padhukasahasram, B., ... Barnes, K. C. (2016). A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nature communications, 7, Article 12522. https://doi.org/10.1038/ncomms12522

@article{b7cdf7fde26d4a16ba9e18b1b3f1f323,

title = "A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome",

abstract = "The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.",

author = "Mathias, {Rasika Ann} and Taub, {Margaret A.} and Gignoux, {Christopher R.} and Wenqing Fu and Shaila Musharoff and O'Connor, {Timothy D.} and Candelaria Vergara and Torgerson, {Dara G.} and Maria Pino-Yanes and Shringarpure, {Suyash S.} and Lili Huang and Nicholas Rafaels and Boorgula, {Meher Preethi} and Johnston, {Henry Richard} and Ortega, {Victor E.} and Levin, {Albert M.} and Wei Song and Raul Torres and Badri Padhukasahasram and Celeste Eng and Mejia-Mejia, {Delmy Aracely} and Trevor Ferguson and Qin, {Zhaohui S.} and Scott, {Alan F.} and Maria Yazdanbakhsh and Wilson, {James G.} and Javier Marrugo and Lange, {Leslie A.} and Rajesh Kumar and Avila, {Pedro C.} and Williams, {L. Keoki} and Harold Watson and Ware, {Lorraine B.} and Christopher Olopade and Olufunmilayo Olopade and Ricardo Oliveira and Carole Ober and Nicolae, {Dan L.} and Deborah Meyers and Alvaro Mayorga and Jennifer Knight-Madden and Tina Hartert and Hansel, {Nadia N.} and Foreman, {Marilyn G.} and Ford, {Jean G.} and Faruque, {Mezbah U.} and Dunston, {Georgia M.} and Luis Caraballo and Burchard, {Esteban G.} and Eugene Bleecker and Araujo, {Maria Ilma} and Herrera-Paz, {Edwin Francisco} and Kimberly Gietzen and Grus, {Wendy E.} and Michael Bamshad and Bustamante, {Carlos D.} and Kenny, {Eimear E.} and Hernandez, {Ryan D.} and Beaty, {Terri H.} and Ingo Ruczinski and Joshua Akey and Barnes, {Kathleen C.}",

year = "2016",

month = oct,

day = "11",

doi = "10.1038/ncomms12522",

language = "English (US)",

volume = "7",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Mathias, RA, Taub, MA, Gignoux, CR, Fu, W, Musharoff, S, O'Connor, TD, Vergara, C, Torgerson, DG, Pino-Yanes, M, Shringarpure, SS, Huang, L, Rafaels, N, Boorgula, MP, Johnston, HR, Ortega, VE, Levin, AM, Song, W, Torres, R, Padhukasahasram, B, Eng, C, Mejia-Mejia, DA, Ferguson, T, Qin, ZS, Scott, AF, Yazdanbakhsh, M, Wilson, JG, Marrugo, J, Lange, LA, Kumar, R, Avila, PC, Williams, LK, Watson, H, Ware, LB, Olopade, C, Olopade, O, Oliveira, R, Ober, C, Nicolae, DL, Meyers, D, Mayorga, A, Knight-Madden, J, Hartert, T, Hansel, NN, Foreman, MG, Ford, JG, Faruque, MU, Dunston, GM, Caraballo, L, Burchard, EG, Bleecker, E, Araujo, MI, Herrera-Paz, EF, Gietzen, K, Grus, WE, Bamshad, M, Bustamante, CD, Kenny, EE, Hernandez, RD, Beaty, TH, Ruczinski, I, Akey, J & Barnes, KC 2016, 'A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome', Nature communications, vol. 7, 12522. https://doi.org/10.1038/ncomms12522

TY - JOUR

T1 - A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

AU - Mathias, Rasika Ann

AU - Taub, Margaret A.

AU - Gignoux, Christopher R.

AU - Fu, Wenqing

AU - Musharoff, Shaila

AU - O'Connor, Timothy D.

AU - Vergara, Candelaria

AU - Torgerson, Dara G.

AU - Pino-Yanes, Maria

AU - Shringarpure, Suyash S.

AU - Huang, Lili

AU - Rafaels, Nicholas

AU - Boorgula, Meher Preethi

AU - Johnston, Henry Richard

AU - Ortega, Victor E.

AU - Levin, Albert M.

AU - Song, Wei

AU - Torres, Raul

AU - Padhukasahasram, Badri

AU - Eng, Celeste

AU - Mejia-Mejia, Delmy Aracely

AU - Ferguson, Trevor

AU - Qin, Zhaohui S.

AU - Scott, Alan F.

AU - Yazdanbakhsh, Maria

AU - Wilson, James G.

AU - Marrugo, Javier

AU - Lange, Leslie A.

AU - Kumar, Rajesh

AU - Avila, Pedro C.

AU - Williams, L. Keoki

AU - Watson, Harold

AU - Ware, Lorraine B.

AU - Olopade, Christopher

AU - Olopade, Olufunmilayo

AU - Oliveira, Ricardo

AU - Ober, Carole

AU - Nicolae, Dan L.

AU - Meyers, Deborah

AU - Mayorga, Alvaro

AU - Knight-Madden, Jennifer

AU - Hartert, Tina

AU - Hansel, Nadia N.

AU - Foreman, Marilyn G.

AU - Ford, Jean G.

AU - Faruque, Mezbah U.

AU - Dunston, Georgia M.

AU - Caraballo, Luis

AU - Burchard, Esteban G.

AU - Bleecker, Eugene

AU - Araujo, Maria Ilma

AU - Herrera-Paz, Edwin Francisco

AU - Gietzen, Kimberly

AU - Grus, Wendy E.

AU - Bamshad, Michael

AU - Bustamante, Carlos D.

AU - Kenny, Eimear E.

AU - Hernandez, Ryan D.

AU - Beaty, Terri H.

AU - Ruczinski, Ingo

AU - Akey, Joshua

AU - Barnes, Kathleen C.

PY - 2016/10/11

Y1 - 2016/10/11

N2 - The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

AB - The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

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UR - http://www.scopus.com/inward/citedby.url?scp=84991369066&partnerID=8YFLogxK

U2 - 10.1038/ncomms12522

DO - 10.1038/ncomms12522

M3 - Article

C2 - 27725671

AN - SCOPUS:84991369066

SN - 2041-1723

VL - 7

JO - Nature communications

JF - Nature communications

M1 - 12522

ER -

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Abstract

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