A concise synthesis of the molecular framework of pleuromutilin

Junjia Liu; Stephen D. Zheng; Erik J. Sorensen

doi:10.1039/c0cc04077k

A concise synthesis of the molecular framework of pleuromutilin

Junjia Liu, Stephen D. Zheng, Erik J. Sorensen

Chemistry

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The congeners prepared are appropriately functionalized to enable access to diverse pleuromutilin analogues.

Original language	English (US)
Pages (from-to)	1500-1502
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	5
DOIs	https://doi.org/10.1039/c0cc04077k
State	Published - Feb 7 2011

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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A concise synthesis of the molecular framework of pleuromutilin

Abstract

All Science Journal Classification (ASJC) codes

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