A concise synthesis of the molecular framework of pleuromutilin

Junjia Liu, Stephen D. Zheng, Erik J. Sorensen

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The congeners prepared are appropriately functionalized to enable access to diverse pleuromutilin analogues.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalChemical Communications
Issue number5
StatePublished - Feb 7 2011

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis


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