A concise and convergent synthesis of PA-824

Maurice A. Marsini; Paul J. Reider; Erik J. Sorensen

doi:10.1021/jo1015807

A concise and convergent synthesis of PA-824

Maurice A. Marsini
, Paul J. Reider
, Erik J. Sorensen

Chemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.

Original language	English (US)
Pages (from-to)	7479-7482
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	75
Issue number	21
DOIs	https://doi.org/10.1021/jo1015807
State	Published - Nov 5 2010

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo1015807

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title = "A concise and convergent synthesis of PA-824",

abstract = "An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.",

author = "Marsini, \{Maurice A.\} and Reider, \{Paul J.\} and Sorensen, \{Erik J.\}",

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AU - Marsini, Maurice A.

AU - Reider, Paul J.

AU - Sorensen, Erik J.

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N2 - An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.

AB - An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 21

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A concise and convergent synthesis of PA-824

Abstract

All Science Journal Classification (ASJC) codes

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