Abstract
Our understanding of biological chemistry is shaped by the observation that all life comes from other life - as Pasteur put it, omne vivum ex vivo. A key step in expanding our biochemical vocabulary is to recapitulate biogenic catalysis using non-natural sequences that did not arise from common ancestry. Here we describe an enzyme designed completely de novo that hydrolyzes ATP. This protein was designed to lack β-sheet structure and is competitively inhibited by magnesium, two traits that are unlike natural ATPases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15230-15234 |
| Number of pages | 5 |
| Journal | Journal of the American Chemical Society |
| Volume | 142 |
| Issue number | 36 |
| DOIs | |
| State | Published - Sep 9 2020 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry
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