Abstract
This study compared the effects of systemically administered 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine (5-HT) and 5-hydroxytryptophan (5-HTP) on tilt cage locomotor activity in rats. 5-HT was a more potent inhibitor of activity than 5-HTP via both the s.c. and i.p. routes. The effect of 5-HT itself was greater when administered i.p., whereas the effects of 5-HTP were independent of the route of administration. These results indicate that behavioral changesfollowing 5-HTP injection may be attributable to the peripheral effects of 5-HT.
Original language | English (US) |
---|---|
Pages (from-to) | 137-139 |
Number of pages | 3 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - 1974 |
All Science Journal Classification (ASJC) codes
- Biological Psychiatry
- Biochemistry
- Behavioral Neuroscience
- Clinical Biochemistry
- Toxicology
- Pharmacology
Keywords
- 5-hydroxytryptamine
- 5-hydroxytryptophan
- Locomotor activity
- Rats