A comparison of the locomotor effects of 5-hydroxytryptamine and 5-hydroxytryptophan administered via two systemic routes

Barry L. Jacobs, Edwin E. Eubanks

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

This study compared the effects of systemically administered 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine (5-HT) and 5-hydroxytryptophan (5-HTP) on tilt cage locomotor activity in rats. 5-HT was a more potent inhibitor of activity than 5-HTP via both the s.c. and i.p. routes. The effect of 5-HT itself was greater when administered i.p., whereas the effects of 5-HTP were independent of the route of administration. These results indicate that behavioral changesfollowing 5-HTP injection may be attributable to the peripheral effects of 5-HT.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1974

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Keywords

  • 5-hydroxytryptamine
  • 5-hydroxytryptophan
  • Locomotor activity
  • Rats

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