@article{5f2133bf169842caabcf9cca929ceee8,
title = "A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory",
abstract = "We systematically compare the contributions of two dopaminergic and two cholinergic ascending populations to a spatial short-term memory task in rats. In ventral tegmental area dopamine (VTA-DA) and nucleus basalis cholinergic (NB-ChAT) populations, trial-by-trial fluctuations in activity during the delay period relate to performance with an inverted-U, despite the fact that both populations have low activity during that time. Transient manipulations reveal that only VTA-DA neurons, and not the other three populations we examine, contribute causally and selectively to short-term memory. This contribution is most significant during the delay period, when both increases and decreases in VTA-DA activity impair short-term memory. Our results reveal a surprising dissociation between when VTA-DA neurons are most active and when they have the biggest causal contribution to short-term memory, and they also provide support for classic ideas about an inverted-U relationship between neuromodulation and cognition.",
keywords = "Inverted-U, Medial septum, Neuromodulation, Nucleus basalis, SNc, Short-term memory, VTA, Working memory, acetylcholine, dopamine",
author = "Choi, {Jung Yoon} and Jang, {Hee Jae} and Sharon Ornelas and Fleming, {Weston T.} and Daniel F{\"u}rth and Jennifer Au and Akhil Bandi and Engel, {Esteban A.} and Witten, {Ilana B.}",
note = "Funding Information: We would like to thank members of the Witten lab for support and advice on this work as well as the PNI viral core, the Center for Neuroanatomy with Neurotropic Viruses (NIH 2P40OD010996-16), Matthias Schnell for providing N2c rabies virus, and Jihyun Bak for providing comments on the manuscript. This research was funded by NYSCF, Pew, McKnight, and NARSAD grants to I.B.W. ARO W911NF1710554, and the following NIH grants: 1R01MH106689-01A1, U19 NS104648-01, DP2 DA035149-01, and 1R01DA047869-01. I.B.W. is a New York Stem Cell Foundation–Robertson Investigator. J.Y.C. and I.B.W. conceived the project and designed the experiments. J.Y.C. H.J. S.O. W.T.F. J.A. and A.B. collected the data. J.Y.C. D.F. and W.T.F. analyzed the data. E.A.E. provided and validated reagents. J.Y.C. and I.B.W. wrote the paper. The authors declare no competing interests. Funding Information: We would like to thank members of the Witten lab for support and advice on this work as well as the PNI viral core, the Center for Neuroanatomy with Neurotropic Viruses ( NIH 2P40OD010996-16 ), Matthias Schnell for providing N2c rabies virus, and Jihyun Bak for providing comments on the manuscript. This research was funded by NYSCF , Pew , McKnight , and NARSAD grants to I.B.W., ARO W911NF1710554 , and the following NIH grants: 1R01MH106689-01A1 , U19 NS104648-01 , DP2 DA035149-01 , and 1R01DA047869-01 . I.B.W. is a New York Stem Cell Foundation–Robertson Investigator. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = dec,
day = "15",
doi = "10.1016/j.celrep.2020.108492",
language = "English (US)",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}