A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila

Ira E. Clark, Krista C. Dobi, Heather K. Duchow, Anna N. Vlasak, Elizabeth R. Gavis

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3′UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional targets of TCE-mediated repression within the nervous system. They also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may function more widely during development to spatially or temporally control gene expression.

Original languageEnglish (US)
Pages (from-to)3325-3334
Number of pages10
JournalDevelopment
Volume129
Issue number14
StatePublished - Jul 1 2002

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • 3′ untranslated region
  • Drosophila
  • Nanos
  • Neuroendocrine
  • Translational control

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