A common neuronal response to alphaherpesvirus infection

Moriah L. Szpara, Oren Kobiler, Lynn W. Enquist

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus-host interaction in these cells. Here, we compare results from seven microarray studies that focused on the host response of either neural tissue or isolated neurons to alphaherpesvirus infection. These studies utilized either herpes simplex virus type 1 or pseudorabies virus as the infectious agent. From these data, we have found common host responses spanning a variety of infection models in different species, with different herpesvirus strains, and during all phases of infection including lytic, latent, and reactivation. The repeated observation of transcriptional effects on these genes and gene families indicates their likely importance in host defenses or the viral infectious process. We discuss the possible role of these different genes and genes families in alphaherpesvirus infection.

Original languageEnglish (US)
Pages (from-to)418-427
Number of pages10
JournalJournal of Neuroimmune Pharmacology
Volume5
Issue number3
DOIs
StatePublished - Sep 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Keywords

  • HSV-1
  • alphaherpesviruses
  • gene expression
  • latency
  • microarray
  • neurons
  • virus

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