A CMOS micro-flow cytometer for magnetic label detection and classification

Pramod Murali, Igor Izyumin, Daniel Joseph Cohen, Jun Chau Chien, Ali M. Niknejad, Bernhard Boser

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

Flow cytometry is widely used in medicine for hematology, immunology, chemotherapy and pathology, as well as in food and water safety. While present instruments are predominantly used in laboratory environments, there is a growing and unmet need for devices that can be used in point-of-care (PoC) settings. The main impediments to PoC solutions are the fluorescent labels, which require sophisticated sample pre-processing and calibration to reduce background, and optics that are difficult to miniaturize. Label-free approaches such as reported in [1] eliminate this problem but have limited applications due to a lack of specificity. Substituting magnetic labels avoids this limitation and eliminates the need for preprocessing, but present solutions use μHall sensors [2] or giant-magneto-resistors (GMRs) [3], which are not available in standard CMOS technology. CMOS LC-tank spectrometry [4] is amenable to integration but does not achieve the bandwidth and sensitivity required for flow cytometry. In this paper, we present a magnetic flow cytometer integrated in standard CMOS technology assembled in a single-use microfluidic cartridge that meets all the above-mentioned requirements.

Original languageEnglish (US)
Title of host publication2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages422-423
Number of pages2
ISBN (Print)9781479909186
DOIs
StatePublished - Jan 1 2014
Externally publishedYes
Event2014 61st IEEE International Solid-State Circuits Conference, ISSCC 2014 - San Francisco, CA, United States
Duration: Feb 9 2014Feb 13 2014

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume57
ISSN (Print)0193-6530

Other

Other2014 61st IEEE International Solid-State Circuits Conference, ISSCC 2014
CountryUnited States
CitySan Francisco, CA
Period2/9/142/13/14

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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    Murali, P., Izyumin, I., Cohen, D. J., Chien, J. C., Niknejad, A. M., & Boser, B. (2014). A CMOS micro-flow cytometer for magnetic label detection and classification. In 2014 IEEE International Solid-State Circuits Conference, ISSCC 2014 - Digest of Technical Papers (pp. 422-423). [6757497] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 57). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2014.6757497