A chemical method for selective labelling of the key amino acid tryptophan

Xiao Xie; Christopher J. Chang

doi:10.1038/d41586-024-00452-7

A chemical method for selective labelling of the key amino acid tryptophan

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.

Original language	English (US)
Journal	Nature
DOIs	https://doi.org/10.1038/d41586-024-00452-7
State	Accepted/In press - 2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

General

Keywords

Chemical biology
Proteomics

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10.1038/d41586-024-00452-7

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title = "A chemical method for selective labelling of the key amino acid tryptophan",

abstract = "A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.",

keywords = "Chemical biology, Proteomics",

author = "Xiao Xie and Chang, {Christopher J.}",

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AU - Chang, Christopher J.

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Y1 - 2024

N2 - A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.

AB - A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.

KW - Chemical biology

KW - Proteomics

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DO - 10.1038/d41586-024-00452-7

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SN - 0028-0836

JO - Nature

JF - Nature

ER -

A chemical method for selective labelling of the key amino acid tryptophan

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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