@article{86a2559623c54dd19364ff24195a91b1,
title = "A C–H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B2",
abstract = "An enantioselective formal synthesis of (−)-aflatoxin B2 from 4-methoxyphenylacetic acid has been achieved by an approach that produces a key carbon–carbon bond, a benzylic stereocenter, and two arene carbon–oxygen bonds in the course of three site-selective C–H functionalizations. The carbonyl-directed acetoxylation of two arene C–H bonds described herein is unprecedented in natural product synthesis and occurs under mild conditions that preserve the configuration of a sensitive benzylic stereocenter.",
author = "Falcone, {Nicholas A.} and Bosse, {Aaron T.} and Hojoon Park and Yu, {Jin Quan} and Davies, {Huw M.L.} and Sorensen, {Erik J.}",
note = "Funding Information: The authors gratefully acknowledge Prof. Julian West (Rice University, Houston, TX) for early intellectual and experimental contributions. The authors thank Prof. Brian Stoltz and Dr. Elizabeth L. Goldstein (California Institute of Technology, Pasadena, CA) for helpful discussions and preliminary studies. Financial support was generously provided by the National Science Foundation under the CCI Center for Selective C–H Functionalization (CHE-1700982). N.A.F. would like to thank the Ted Taylor Fellowship (Princeton University) for funding. Dr. Istv{\'a}n Pelczer (Princeton University), Kenith Conover (Princeton University), and Dr. John Eng (Princeton University) are acknowledged for analytical assistance. Publisher Copyright: {\textcopyright} 2021 American Chemical Society",
year = "2021",
month = dec,
day = "17",
doi = "10.1021/acs.orglett.1c03502",
language = "English (US)",
volume = "23",
pages = "9393--9397",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "24",
}