Abstract
An enantioselective formal synthesis of (−)-aflatoxin B2 from 4-methoxyphenylacetic acid has been achieved by an approach that produces a key carbon–carbon bond, a benzylic stereocenter, and two arene carbon–oxygen bonds in the course of three site-selective C–H functionalizations. The carbonyl-directed acetoxylation of two arene C–H bonds described herein is unprecedented in natural product synthesis and occurs under mild conditions that preserve the configuration of a sensitive benzylic stereocenter.
Original language | English (US) |
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Pages (from-to) | 9393-9397 |
Number of pages | 5 |
Journal | Organic letters |
Volume | 23 |
Issue number | 24 |
DOIs | |
State | Published - Dec 17 2021 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry