A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Materials Chemistry B|
|State||Published - Mar 21 2014|
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Materials Science(all)