A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

Shivani Singh; Stephen B. Bandini; Patrick E. Donnelly; Jeffrey Schwartz; Jean E. Schwarzbauer

doi:10.1039/c3tb21864c

A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

Shivani Singh, Stephen B. Bandini, Patrick E. Donnelly, Jeffrey Schwartz, Jean E. Schwarzbauer

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.

Original language	English (US)
Pages (from-to)	1449-1453
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	11
DOIs	https://doi.org/10.1039/c3tb21864c
State	Published - Mar 21 2014

All Science Journal Classification (ASJC) codes

General Chemistry
Biomedical Engineering
General Materials Science

Access to Document

10.1039/c3tb21864c

Cite this

@article{26cc02ce3e4243a1a93a6292d5cc87e9,

title = "A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development",

abstract = "A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.",

author = "Shivani Singh and Bandini, {Stephen B.} and Donnelly, {Patrick E.} and Jeffrey Schwartz and Schwarzbauer, {Jean E.}",

year = "2014",

month = mar,

day = "21",

doi = "10.1039/c3tb21864c",

language = "English (US)",

volume = "2",

pages = "1449--1453",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

AU - Singh, Shivani

AU - Bandini, Stephen B.

AU - Donnelly, Patrick E.

AU - Schwartz, Jeffrey

AU - Schwarzbauer, Jean E.

PY - 2014/3/21

Y1 - 2014/3/21

N2 - A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.

AB - A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.

UR - http://www.scopus.com/inward/record.url?scp=84894468827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894468827&partnerID=8YFLogxK

U2 - 10.1039/c3tb21864c

DO - 10.1039/c3tb21864c

M3 - Article

AN - SCOPUS:84894468827

SN - 2050-7518

VL - 2

SP - 1449

EP - 1453

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 11

ER -

A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this