A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

Shivani Singh, Stephen B. Bandini, Patrick E. Donnelly, Jeffrey Schwartz, Jean E. Schwarzbauer

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.

Original languageEnglish (US)
Pages (from-to)1449-1453
Number of pages5
JournalJournal of Materials Chemistry B
Volume2
Issue number11
DOIs
StatePublished - Mar 21 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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