@article{7aed54af6b7c45e29994842aac7a2591,
title = "A biohybrid strategy for enabling photoredox catalysis with low-energy light",
abstract = "Natural systems drive the high-energy reactions of photosynthesis with efficient and broadband energy capture. Transition-metal photocatalysts similarly convert light into chemical reactivity, and yet suffer from light-limited operation and require blue-to-UV excitation. In photosynthesis, both light capture and reactivity have been optimized by separation into distinct sites. Inspired by this modular architecture, we synthesized a biohybrid photocatalyst by covalent attachment of the photosynthetic light-harvesting protein R-phycoerythrin (RPE) to the transition-metal photocatalyst tris(2,2′-bipyridine)ruthenium(II) ([Ru(bpy)3]2+). Spectroscopic investigation found that absorbed photoenergy was efficiently funneled from RPE to [Ru(bpy)3]2+. The utility of the biohybrid photocatalyst was demonstrated via an increase in yields for a thiol-ene coupling reaction and a cysteinyl-desulfurization reaction, including recovered reactivity at red wavelengths where [Ru(bpy)3]2+ alone does not absorb.",
keywords = "SDG12: Responsible consumption and production, SDG7: Affordable and clean energy, biohybrid, energy transfer, photoredox catalysis, photosynthetic light harvesting",
author = "Cesana, {Paul T.} and Li, {Beryl X.} and Shepard, {Samuel G.} and Ting, {Stephen I.} and Hart, {Stephanie M.} and Olson, {Courtney M.} and {Martinez Alvarado}, {Jesus I.} and Minjung Son and Steiman, {Talia J.} and Castellano, {Felix N.} and Doyle, {Abigail G.} and MacMillan, {David W.C.} and Schlau-Cohen, {Gabriela S.}",
note = "Funding Information: This work was supported as part of BioLEC , an Energy Frontier Research Center funded by the U.S. Department of Energy , Office of Science under award # DE-SC0019370. The authors acknowledge Antonius Koller of the Koch Institute for Integrative Cancer Research at MIT for the intact MS measurements. Funding Information: This work was supported as part of BioLEC, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science under award # DE-SC0019370. The authors acknowledge Antonius Koller of the Koch Institute for Integrative Cancer Research at MIT for the intact MS measurements. Conceptualization: P.T.C. B.X.L. C.M.O. M.S. T.J.S. F.N.C. A.G.D. D.W.C.M. and G.S.S-C.; resources: P.T.C. C.M.O. S.M.H. M.S. and T.J.S.; investigation: P.T.C. S.M.H. S.G.S. B.X.L. S.I.T. and J.I.M.A.; writing?original draft: P.T.C. B.X.L. and G.S.S-C.; writing?review and editing: P.T.C. B.X.L. S.I.T. S.G.S. J.I.M.A. F.N.C. A.G.D. D.W.C.M. and G.S.S-C.; funding acquisition: F.N.C. A.G.D. D.W.C.M. and G.S.S-C.; supervision: F.N.C. A.G.D. D.W.C.M. and G.S.S-C. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2022",
month = jan,
day = "13",
doi = "10.1016/j.chempr.2021.10.010",
language = "English (US)",
volume = "8",
pages = "174--185",
journal = "Chem",
issn = "2451-9294",
publisher = "Elsevier Inc.",
number = "1",
}