Abstract
This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant ∼30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 264-267 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 955 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 15 2002 |
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Molecular Biology
- General Neuroscience
- Developmental Biology
Keywords
- 5-HT receptor
- Dentate gyrus
- Granule cell
- Hippocampus
- Neurogenesis
- Serotonin
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