5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Jason J. Radley, Barry Jacobs

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant ∼30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalBrain Research
Volume955
Issue number1-2
DOIs
StatePublished - Nov 15 2002

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • 5-HT receptor
  • Dentate gyrus
  • Granule cell
  • Hippocampus
  • Neurogenesis
  • Serotonin

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