5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Jason J. Radley; Barry L. Jacobs

doi:10.1016/S0006-8993(02)03477-7

5-HT_1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Jason J. Radley, Barry L. Jacobs

Psychology

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

This study investigated the action of 5-HT_1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant ∼30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT_1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

Original language	English (US)
Pages (from-to)	264-267
Number of pages	4
Journal	Brain Research
Volume	955
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03477-7
State	Published - Nov 15 2002

All Science Journal Classification (ASJC) codes

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

Keywords

5-HT receptor
Dentate gyrus
Granule cell
Hippocampus
Neurogenesis
Serotonin

Access to Document

10.1016/S0006-8993(02)03477-7

Cite this

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