5-HT and motor control: a hypothesis

Barry L. Jacobs; Casimir A. Fornal

doi:10.1016/0166-2236(93)90090-9

5-HT and motor control: a hypothesis

Barry L. Jacobs, Casimir A. Fornal

Psychology

Research output: Contribution to journal › Comment/debate › peer-review

205 Scopus citations

Abstract

The activity of 5-HT-containing neurons in the brain is activated preferentially in association with motor output in cats. This is especially apparent during changes in muscle tone and during responses mediated by central pattern generators; such as chewing, locomotion and respiration. These and other data support the hypothesis that the primary functions of the 5-HT system in the brain are to facilitate motor output and concurrently inhibit sensory information processing. This hypothesis is applicable phylogenetically, from invertebrates to mammals.

Original language	English (US)
Pages (from-to)	346-352
Number of pages	7
Journal	Trends in Neurosciences
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/0166-2236(93)90090-9
State	Published - Sep 1993

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/0166-2236(93)90090-9

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abstract = "The activity of 5-HT-containing neurons in the brain is activated preferentially in association with motor output in cats. This is especially apparent during changes in muscle tone and during responses mediated by central pattern generators; such as chewing, locomotion and respiration. These and other data support the hypothesis that the primary functions of the 5-HT system in the brain are to facilitate motor output and concurrently inhibit sensory information processing. This hypothesis is applicable phylogenetically, from invertebrates to mammals.",

author = "Jacobs, {Barry L.} and Fornal, {Casimir A.}",

note = "Funding Information: by grants from the 43 Kravitz, E. A. (1988) Science 241, 1775-1781 172-182 AFOSR (90-0294) 44 Ma, P. M., Beltz, B. S. and Kravitz, E. A. (1992) and the NIMH (MH J. Neurophysiol. 68, 36-54 23433). 45 Kupfermann, I. and Weiss, K. R. (1981) in 5erotonin Neurotransmission and Behavior (Jacobs, B. L, and Gelperin,",

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N2 - The activity of 5-HT-containing neurons in the brain is activated preferentially in association with motor output in cats. This is especially apparent during changes in muscle tone and during responses mediated by central pattern generators; such as chewing, locomotion and respiration. These and other data support the hypothesis that the primary functions of the 5-HT system in the brain are to facilitate motor output and concurrently inhibit sensory information processing. This hypothesis is applicable phylogenetically, from invertebrates to mammals.

AB - The activity of 5-HT-containing neurons in the brain is activated preferentially in association with motor output in cats. This is especially apparent during changes in muscle tone and during responses mediated by central pattern generators; such as chewing, locomotion and respiration. These and other data support the hypothesis that the primary functions of the 5-HT system in the brain are to facilitate motor output and concurrently inhibit sensory information processing. This hypothesis is applicable phylogenetically, from invertebrates to mammals.

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5-HT and motor control: a hypothesis

Abstract

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