3Dπ: three-dimensional positron imaging, a novel total-body PET scanner using xenon-doped liquid argon scintillator

Objective. This paper introduces a novel PET imaging methodology called 3-dimensional positron imaging (3Dπ), which integrates total-body coverage, time-of-flight (TOF) technology, ultra-low dose imaging capabilities, and ultra-fast readout electronics inspired by emerging technology from the DarkSide collaboration. Approach. The study evaluates the performance of 3Dπ using Monte Carlo simulations based on NEMA NU 2-2018 protocols. The methodology employs a homogenous, monolithic scintillator composed of liquid argon (LAr) doped with xenon (Xe) with silicon photomultipliers (SiPMs) operating at cryogenic temperatures. Main results. Substantial improvements in system performance are observed, with the 3Dπ system achieving a noise equivalent count rate of 3.2 Mcps at 17.3 kBq ml⁻¹, continuing to increase up to 4.3 Mcps at 40 kBq ml⁻¹. Spatial resolution measurements show an average FWHM of 2.7 mm across both axial positions. The system exhibits superior sensitivity, with values reaching 373 kcps MBq⁻¹ with a line source at the center of the field of view. Additionally, 3Dπ achieves a TOF resolution of 151 ps at 5.3 kBq ml⁻¹, highlighting its potential to produce high-quality images with reduced noise levels. Significance. The study underscores the potential of 3Dπ in improving PET imaging performance, offering the potential for shorter scan times and reduced radiation exposure for patients. The Xe-doped LAr offers advantages such as fast scintillation, enhanced light yield, and cost-effectiveness. Future research will focus on optimizing system geometry and further refining reconstruction algorithms to exploit the strengths of 3Dπ for clinical applications.