[2.2]PHANEPHOS-ruthenium(II) complexes: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

Philip J. Pye; Kai Rossen; Robert A. Reamer; R. P. Volante; Paul J. Reider

doi:10.1016/S0040-4039(98)00842-9

[2.2]PHANEPHOS-ruthenium(II) complexes: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

Philip J. Pye, Kai Rossen, Robert A. Reamer, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.

Original language	English (US)
Pages (from-to)	4441-4444
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(98)00842-9
State	Published - Jun 18 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)00842-9

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abstract = "The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96\% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.",

author = "Pye, \{Philip J.\} and Kai Rossen and Reamer, \{Robert A.\} and Volante, \{R. P.\} and Reider, \{Paul J.\}",

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T2 - Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

AU - Pye, Philip J.

AU - Rossen, Kai

AU - Reamer, Robert A.

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 1998/6/18

Y1 - 1998/6/18

N2 - The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.

AB - The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.

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U2 - 10.1016/S0040-4039(98)00842-9

DO - 10.1016/S0040-4039(98)00842-9

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IS - 25

ER -

[2.2]PHANEPHOS-ruthenium(II) complexes: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

Abstract

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