[2.2]PHANEPHOS-ruthenium(II) complexes: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

Philip J. Pye, Kai Rossen, Robert A. Reamer, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.

Original languageEnglish (US)
Pages (from-to)4441-4444
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number25
DOIs
StatePublished - Jun 18 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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