The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of β-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 18 1998|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry