22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

M. Reza Pazhouhandeh; Gerard Orleary; Iliya Weisspapir; David Groppe; Xuan Thuan Nguyen; Karim Abdelhalim; Hamed Mazhab Jafari; Taufik A. Valiante; Peter Carlen; Naveen Verma; Roman Genov

doi:10.1109/ISSCC.2019.8662458

22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

M. Reza Pazhouhandeh, Gerard Orleary, Iliya Weisspapir, David Groppe, Xuan Thuan Nguyen, Karim Abdelhalim, Hamed Mazhab Jafari, Taufik A. Valiante, Peter Carlen, Naveen Verma, Roman Genov

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

26 Scopus citations

Abstract

An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.

Original language	English (US)
Title of host publication	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	374-376
Number of pages	3
ISBN (Electronic)	9781538685310
DOIs	https://doi.org/10.1109/ISSCC.2019.8662458
State	Published - Mar 6 2019
Event	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States Duration: Feb 17 2019 → Feb 21 2019

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	2019-February
ISSN (Print)	0193-6530

Conference

Conference	2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
Country/Territory	United States
City	San Francisco
Period	2/17/19 → 2/21/19

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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10.1109/ISSCC.2019.8662458

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Pazhouhandeh, M. R., Orleary, G., Weisspapir, I., Groppe, D., Nguyen, X. T., Abdelhalim, K., Jafari, H. M., Valiante, T. A., Carlen, P., Verma, N., & Genov, R. (2019). 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 (pp. 374-376). Article 8662458 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2019.8662458

Pazhouhandeh, M. Reza ; Orleary, Gerard ; Weisspapir, Iliya et al. / 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 374-376 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).

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title = "22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications",

abstract = "An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.",

author = "Pazhouhandeh, {M. Reza} and Gerard Orleary and Iliya Weisspapir and David Groppe and Nguyen, {Xuan Thuan} and Karim Abdelhalim and Jafari, {Hamed Mazhab} and Valiante, {Taufik A.} and Peter Carlen and Naveen Verma and Roman Genov",

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Pazhouhandeh, MR, Orleary, G, Weisspapir, I, Groppe, D, Nguyen, XT, Abdelhalim, K, Jafari, HM, Valiante, TA, Carlen, P, Verma, N & Genov, R 2019, 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. in 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019., 8662458, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 2019-February, Institute of Electrical and Electronics Engineers Inc., pp. 374-376, 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019, San Francisco, United States, 2/17/19. https://doi.org/10.1109/ISSCC.2019.8662458

22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. / Pazhouhandeh, M. Reza; Orleary, Gerard; Weisspapir, Iliya et al.
2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 374-376 8662458 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Pazhouhandeh, M. Reza

AU - Orleary, Gerard

AU - Weisspapir, Iliya

AU - Groppe, David

AU - Nguyen, Xuan Thuan

AU - Abdelhalim, Karim

AU - Jafari, Hamed Mazhab

AU - Valiante, Taufik A.

AU - Carlen, Peter

AU - Verma, Naveen

AU - Genov, Roman

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AB - An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.

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Pazhouhandeh MR, Orleary G, Weisspapir I, Groppe D, Nguyen XT, Abdelhalim K et al. 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 374-376. 8662458. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC.2019.8662458

22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

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