γδ T cells unveil invisible tumors

Hui Fern Koay; Lydia Lynch

doi:10.1016/j.it.2023.01.011

γδ T cells unveil invisible tumors

Hui Fern Koay, Lydia Lynch

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.

Original language	English (US)
Pages (from-to)	159-161
Number of pages	3
Journal	Trends in Immunology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.it.2023.01.011
State	Published - Mar 2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/j.it.2023.01.011

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title = "γδ T cells unveil invisible tumors",

abstract = "Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.",

author = "Koay, {Hui Fern} and Lydia Lynch",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = mar,

doi = "10.1016/j.it.2023.01.011",

language = "English (US)",

volume = "44",

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journal = "Trends in Immunology",

issn = "1471-4906",

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T1 - γδ T cells unveil invisible tumors

AU - Koay, Hui Fern

AU - Lynch, Lydia

PY - 2023/3

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N2 - Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.

AB - Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.

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U2 - 10.1016/j.it.2023.01.011

DO - 10.1016/j.it.2023.01.011

M3 - Short survey

C2 - 36754745

AN - SCOPUS:85148096522

SN - 1471-4906

VL - 44

SP - 159

EP - 161

JO - Trends in Immunology

JF - Trends in Immunology

IS - 3

ER -

γδ T cells unveil invisible tumors

Abstract

All Science Journal Classification (ASJC) codes

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