γδ T cells as unconventional targets of checkpoint blockade

Hans R. Widlund; Lydia Lynch

doi:10.1038/s43018-024-00735-y

γδ T cells as unconventional targets of checkpoint blockade

Hans R. Widlund, Lydia Lynch

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1⁺ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1⁺ Vδ1⁺ T cells are repressed after engagement of PD-1 by PD-L1.

Original language	English (US)
Pages (from-to)	373-374
Number of pages	2
Journal	Nature Cancer
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/s43018-024-00735-y
State	Published - Mar 2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/s43018-024-00735-y

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abstract = "Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.",

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AU - Lynch, Lydia

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N2 - Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.

AB - Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.

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γδ T cells as unconventional targets of checkpoint blockade

Abstract

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