β-catenin mediates stress resilience through Dicer1/microRNA regulation

Caroline Dias; Jian Feng; Haosheng Sun; Ning Yi Shao; Michelle S. Mazei-Robison; Diane Damez-Werno; Kimberly Scobie; Rosemary Bagot; Benoit Labonté; Efrain Ribeiro; Xiaochuan Liu; Pamela Kennedy; Vincent Vialou; Deveroux Ferguson; Catherine Penã; Erin S. Calipari; Ja Wook Koo; Ezekiell Mouzon; Subroto Ghose; Carol Tamminga; Rachael Neve; Li Shen; Eric J. Nestler

doi:10.1038/nature13976

β-catenin mediates stress resilience through Dicer1/microRNA regulation

Caroline Dias, Jian Feng, Haosheng Sun, Ning Yi Shao, Michelle S. Mazei-Robison, Diane Damez-Werno, Kimberly Scobie, Rosemary Bagot, Benoit Labonté, Efrain Ribeiro, Xiaochuan Liu, Pamela Kennedy, Vincent Vialou, Deveroux Ferguson, Catherine Penã, Erin S. Calipari, Ja Wook Koo, Ezekiell Mouzon, Subroto Ghose, Carol TammingaRachael Neve, Li Shen, Eric J. Nestler

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192 Scopus citations

Abstract

β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis-as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.

Original language	English (US)
Pages (from-to)	S1-S5
Journal	Nature
Volume	516
Issue number	729
DOIs	https://doi.org/10.1038/nature13976
State	Published - Dec 4 2014
Externally published	Yes

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Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., Labonté, B., Ribeiro, E., Liu, X., Kennedy, P., Vialou, V., Ferguson, D., Penã, C., Calipari, E. S., Koo, J. W., Mouzon, E., Ghose, S., ... Nestler, E. J. (2014). β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature, 516(729), S1-S5. https://doi.org/10.1038/nature13976

@article{85474ee748b9420589dda05941a3ee30,

title = "β-catenin mediates stress resilience through Dicer1/microRNA regulation",

abstract = "β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis-as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.",

author = "Caroline Dias and Jian Feng and Haosheng Sun and Shao, {Ning Yi} and Mazei-Robison, {Michelle S.} and Diane Damez-Werno and Kimberly Scobie and Rosemary Bagot and Benoit Labont{\'e} and Efrain Ribeiro and Xiaochuan Liu and Pamela Kennedy and Vincent Vialou and Deveroux Ferguson and Catherine Pen{\~a} and Calipari, {Erin S.} and Koo, {Ja Wook} and Ezekiell Mouzon and Subroto Ghose and Carol Tamminga and Rachael Neve and Li Shen and Nestler, {Eric J.}",

note = "Publisher Copyright: {\textcopyright} 2014 Macmillan Publishers Limited.",

year = "2014",

month = dec,

day = "4",

doi = "10.1038/nature13976",

language = "English (US)",

volume = "516",

pages = "S1--S5",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

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Dias, C, Feng, J, Sun, H, Shao, NY, Mazei-Robison, MS, Damez-Werno, D, Scobie, K, Bagot, R, Labonté, B, Ribeiro, E, Liu, X, Kennedy, P, Vialou, V, Ferguson, D, Penã, C, Calipari, ES, Koo, JW, Mouzon, E, Ghose, S, Tamminga, C, Neve, R, Shen, L & Nestler, EJ 2014, 'β-catenin mediates stress resilience through Dicer1/microRNA regulation', Nature, vol. 516, no. 729, pp. S1-S5. https://doi.org/10.1038/nature13976

TY - JOUR

T1 - β-catenin mediates stress resilience through Dicer1/microRNA regulation

AU - Dias, Caroline

AU - Feng, Jian

AU - Sun, Haosheng

AU - Shao, Ning Yi

AU - Mazei-Robison, Michelle S.

AU - Damez-Werno, Diane

AU - Scobie, Kimberly

AU - Bagot, Rosemary

AU - Labonté, Benoit

AU - Ribeiro, Efrain

AU - Liu, Xiaochuan

AU - Kennedy, Pamela

AU - Vialou, Vincent

AU - Ferguson, Deveroux

AU - Penã, Catherine

AU - Calipari, Erin S.

AU - Koo, Ja Wook

AU - Mouzon, Ezekiell

AU - Ghose, Subroto

AU - Tamminga, Carol

AU - Neve, Rachael

AU - Shen, Li

AU - Nestler, Eric J.

PY - 2014/12/4

Y1 - 2014/12/4

N2 - β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis-as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.

AB - β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis-as a β-catenin target gene that mediates resilience. Small RNA profiling after excising β-catenin from nucleus accumbens in the context of chronic stress reveals β-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish β-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.

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U2 - 10.1038/nature13976

DO - 10.1038/nature13976

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C2 - 25383518

AN - SCOPUS:84923168061

SN - 0028-0836

VL - 516

SP - S1-S5

JO - Nature

JF - Nature

IS - 729

ER -

β-catenin mediates stress resilience through Dicer1/microRNA regulation

Abstract

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