• 16136 Citations
  • 65 h-Index
1973 …2018
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1973 2018

2018
2 Citations (Scopus)

Improving support for young biomedical scientists

Alberts, B., Hyman, T., Pickett, C. L., Tilghman, S. M. & Varmus, H., May 18 2018, In : Science. 360, 6390, p. 716-718 3 p.

Research output: Contribution to journalReview article

young population
research work
European Union
education
young
2017

Not just Salk

Greider, C., Hopkins, N., Steitz, J., Amon, A., Asai, D., Barres, B., Bass, B., Bassler, B. L., Birgeneau, R., Bjorkman, P., Botchan, M., Brugge, J., Cech, T., Colwell, R., Craig, N., Delange, T., Eisen, M., Gottesman, S., Green, R., Handelsman, J. & 17 others, Kimble, J., King, M. C., Lehmann, R., Marder, E., Mullins, D., O’Shea, E., Schmid, S., Seydoux, G., Spradling, A., Storz, G., Szostak, J., Telesnitsky, A., Tilghman, S. M., Tjian, R., Vale, R., Wolberger, C. & Zakian, V. A., Sep 15 2017, In : Science. 357, 6356, p. 1105-1106 2 p.

Research output: Contribution to journalLetter

2015
31 Citations (Scopus)

Opinion: Addressing systemic problems in the biomedical research enterprise

Alberts, B., Kirschner, M. W., Tilghman, S. M. & Varmusd, H., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 1912-1913 2 p.

Research output: Contribution to journalComment/debate

Biomedical Research
2014
334 Citations (Scopus)

Rescuing US biomedical research from its systemic flaws

Alberts, B., Kirschner, M. W., Tilghman, S. M. & Varmus, H., Apr 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 5773-5777 5 p.

Research output: Contribution to journalReview article

Ecosystem
Biomedical Research
Hand
Research Personnel
Students

Twists and turns: a scientific journey

Tilghman, S. M., Jan 1 2014, In : Annual review of cell and developmental biology. 30, p. 1-21 21 p.

Research output: Contribution to journalArticle

Mammalian Embryo
Creativity
Molecular Biology
Students
Gene Expression
2010

It's all about the talent.

Tilghman, S. M., Jan 1 2010, In : Molecular biology of the cell. 21, 22, 1 p.

Research output: Contribution to journalArticle

Career Mobility
Personnel Selection
Aptitude
Cell Biology
Research Personnel
2007
4 Citations (Scopus)

Expanding equal opportunity: The Princeton experience with financial aid

Tilghman, S. M., Jan 1 2007, In : Harvard Educational Review. 77, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

financial aid
equal opportunity
loan
experience
student
2006
305 Citations (Scopus)

Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes

Mancini-DiNardo, D., Steele, S. J. S., Levorse, J. M., Ingram, R. S. & Tilghman, S. M., May 15 2006, In : Genes and Development. 20, 10, p. 1268-1282 15 p.

Research output: Contribution to journalArticle

Genomic Imprinting
KCNQ1 Potassium Channel
Genes
CpG Islands
Chromosomes, Human, Pair 7
Graduate Education
Untranslated RNA
interviews
Interviews
Research
2005
15 Citations (Scopus)

Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region

Katz, D. J., Beer, M. A., Levorse, J. M. & Tilghman, S. M., May 1 2005, In : Molecular and cellular biology. 25, 10, p. 3855-3863 9 p.

Research output: Contribution to journalArticle

Binding Sites
Retroelements
Chromatin Immunoprecipitation
DNA
Zinc Fingers
63 Citations (Scopus)

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Hakimi, P., Johnson, M. T., Yang, J., Lepage, D. F., Conlon, R. A., Kalhan, S. C., Reshef, L., Tilghman, S. M. & Hanson, R. W., Nov 21 2005, In : Nutrition and Metabolism. 2, 33.

Research output: Contribution to journalArticle

Phosphoenolpyruvate
Liver
Parturition
Triglycerides
Citric Acid Cycle
2004
556 Citations (Scopus)

Scientific Teaching

Handelsman, J., Ebert-May, D., Beichner, R., Bruns, P., Chang, A., DeHaan, R., Gentile, J., Lauffer, S., Stewart, J., Tilghman, S. M. & Wood, W. B., Apr 23 2004, In : Science. 304, 5670, p. 521-522 2 p.

Research output: Contribution to journalShort survey

Teaching Materials
Graduate Education
curriculum
Curriculum
teaching
2003
102 Citations (Scopus)

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

Mancini-DiNardo, D., Steele, S. J. S., Ingram, R. S. & Tilghman, S. M., Feb 1 2003, In : Human molecular genetics. 12, 3, p. 283-294 12 p.

Research output: Contribution to journalReview article

Genes
CpG Islands
Chromosomes, Human, Pair 7
Ataxia
Multigene Family
47 Citations (Scopus)

An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina

Semenova, E., Wang, X. F., Jablonski, M. M., Levorse, J. & Tilghman, S. M., Jun 1 2003, In : Human molecular genetics. 12, 11, p. 1301-1312 12 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 14
Retina
Muscles
Homozygote
Growth
228 Citations (Scopus)

CTCF maintains differential methylation at the Igf2/H19 locus

Schoenherr, C. J., Levorse, J. M. & Tilghman, S. M., Jan 1 2003, In : Nature Genetics. 33, 1, p. 66-69 4 p.

Research output: Contribution to journalArticle

Somatomedins
Methylation
Mothers
Genomic Imprinting
Oogenesis
15 Citations (Scopus)

Functional Characterization of a Testis-Specific DNA Binding Activity at the H19/Igf2 Imprinting Control Region

Bowman, A. B., Levorse, J. M., Ingram, R. S. & Tilghman, S. M., Nov 1 2003, In : Molecular and cellular biology. 23, 22, p. 8345-8351 7 p.

Research output: Contribution to journalArticle

Germ Cells
Testis
DNA Methylation
Epigenomics
DNA
55 Citations (Scopus)

Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta

Sandell, L. L., Guan, X. J., Ingram, R. & Tilghman, S. M., Apr 15 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 8, p. 4622-4627 6 p.

Research output: Contribution to journalArticle

Creatine
Placenta
Enzymes
Genes
CpG Islands
272 Citations (Scopus)

Glyceroneogenesis and the triglyceride/fatty acid cycle

Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M. & Hanson, R. W., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30413-30416 4 p.

Research output: Contribution to journalShort survey

Liver
Glycerol
Adipose Tissue
Animals
Triglycerides
2002
14 Citations (Scopus)

A human H19 transgene exhibits impaired paternal-specific imprint acquisition and maintenance in mice

Jones, B. K., Levorse, J. & Tilghman, S. M., Feb 15 2002, In : Human Molecular Genetics. 11, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Transgenes
Maintenance
Methylation
Genes
Genomic Imprinting
106 Citations (Scopus)

A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice

Olswang, Y., Cohen, H., Papo, O., Cassuto, H., Croniger, C. M., Hakimi, P., Tilghman, S. M., Hanson, R. W. & Reshef, L., Jan 22 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 2, p. 625-630 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Phosphoenolpyruvate
Adipose Tissue
Fats
Binding Sites
14 Citations (Scopus)

Candidate genes required for embryonic development: A comparative analysis of distal mouse chromosome 14 and human chromosome 13q22

Kurihara, L. J., Semenova, E., Miller, W., Ingram, R. S., Guan, X. J. & Tilghman, S. M., Feb 1 2002, In : Genomics. 79, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 14
Human Chromosomes
Embryonic Development
Genes
Multigene Family
92 Citations (Scopus)

Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis

Cole, S. E., Levorse, J. M., Tilghman, S. M. & Vogt, T. F., Jan 1 2002, In : Developmental cell. 3, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

Somites
Mesoderm
Clocks
Basic Helix-Loop-Helix Transcription Factors
Nucleic Acid Regulatory Sequences
27 Citations (Scopus)

Phosphoenolpyruvate carboxykinase revisited: Insights into its metabolic role

Croniger, C. M., Olswang, Y., Reshef, L., Kalhan, S. C., Tilghman, S. M. & Hanson, R. W., Jan 1 2002, In : Biochemistry and Molecular Biology Education. 30, 1, p. 14-20 7 p.

Research output: Contribution to journalReview article

Phosphoenolpyruvate

Shirley Tilghman, PhD.

Tilghman, S. M., Jan 1 2002, In : New Jersey Medicine : the journal of the Medical Society of New Jersey. 99, 3, p. 14-20 7 p.

Research output: Contribution to journalArticle

20th Century History
Genomics
Administrative Personnel
Biochemistry
2001
60 Citations (Scopus)

Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity

Jones, B. K., Levorse, J. & Tilghman, S. M., Apr 1 2001, In : Human Molecular Genetics. 10, 8, p. 807-814 8 p.

Research output: Contribution to journalArticle

Adiposity
Somatomedins
Genes
Chromatin
Brain
45 Citations (Scopus)

Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice

Cleary, M. A., Van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A. & Tilghman, S. M., Sep 12 2001, In : Nature Genetics. 29, 1, p. 78-82 5 p.

Research output: Contribution to journalArticle

Genetic Translocation
Multigene Family
Genes
Genomic Imprinting
Chromosomes, Human, Pair 7
23 Citations (Scopus)

Genomic imprinting of a placental lactogen gene in Peromyscus

Vrana, P. B., Matteson, P. G., Schmidt, J. V., Ingram, R. S., Joyce, A., Prince, K. L., Dewey, M. J. & Tilghman, S. M., Dec 1 2001, In : Development Genes and Evolution. 211, 11, p. 523-532 10 p.

Research output: Contribution to journalArticle

Peromyscus
Genomic Imprinting
Placental Lactogen
Genes
Fetal Development
75 Citations (Scopus)

Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

Kurihara, L. J., Kikuchi, T., Wada, K. & Tilghman, S. M., Sep 1 2001, In : Human Molecular Genetics. 10, 18, p. 1963-1970 8 p.

Research output: Contribution to journalArticle

Ubiquitin Thiolesterase
Homozygote
Deglutition Disorders
Paralysis
Solitary Nucleus
15 Citations (Scopus)

Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization.

van Raamsdonk, C. D. & Tilghman, S. M., Jan 1 2001, In : Nucleic acids research. 29, 8

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
RNA
Genes
Fluorescent Dyes
Genome
2000
143 Citations (Scopus)

Allelic expression of IGF2 in marsupials and birds

O'Neill, M. J., Ingram, R. S., Vrana, P. B. & Tilghman, S. M., Jan 1 2000, In : Development Genes and Evolution. 210, 1, p. 18-20 3 p.

Research output: Contribution to journalArticle

Marsupialia
Birds
Genes
Mothers
Gene Expression
1086 Citations (Scopus)

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M. & Tilghman, S. M., May 25 2000, In : Nature. 405, 6785, p. 486-489 4 p.

Research output: Contribution to journalArticle

Somatomedins
Methylation
Chromatin
Vertebrates
Chromosomes
87 Citations (Scopus)

Dosage requirement and allelic expression of PAX6 during lens placode formation

van Raamsdonk, C. D. & Tilghman, S. M., Dec 1 2000, In : Development. 127, 24, p. 5439-5448 10 p.

Research output: Contribution to journalArticle

Lenses
Embryonic Structures
Heterozygote
Paired Box Transcription Factors
Cell Count
83 Citations (Scopus)

Exploring genome space

Vukmirovic, O. G. & Tilghman, S. M., Jun 15 2000, In : Nature. 405, 6788, p. 820-822 3 p.

Research output: Contribution to journalReview article

Genome
Human Genome
Technology
60 Citations (Scopus)

Expression and functional analysis of Uch-L3 during mouse development

Kurihara, L. J., Semenova, E., Levorse, J. M. & Tilghman, S. M., Apr 1 2000, In : Molecular and cellular biology. 20, 7, p. 2498-2504 7 p.

Research output: Contribution to journalArticle

Ubiquitin Thiolesterase
Phenotype
Mutation
Homozygote
Thymus Gland
128 Citations (Scopus)

Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in peromyscus

Vrana, P. B., Fossella, J. A., Matteson, P., Del Rio, T., O'Neill, M. J. & Tilghman, S. M., May 1 2000, In : Nature Genetics. 25, 1, p. 120-124 5 p.

Research output: Contribution to journalArticle

Peromyscus
Epigenomics
Reproductive Isolation
X Chromosome Inactivation
X Chromosome
20 Citations (Scopus)

Spatially restricted hypopigmentation associated with an Ednrb(s)-modifying locus on mouse chromosome 10

Rhim, H., Dunn, K. J., Aronzon, A., Susanna, M., Cheng, M., Lamoreux, M. L., Tilghman, S. M. & Pavan, W. J., Jan 1 2000, In : Genome Research. 10, 1, p. 17-29 13 p.

Research output: Contribution to journalArticle

Hypopigmentation
Chromosomes, Human, Pair 10
Alleles
Metrorrhagia
Stem Cell Factor
250 Citations (Scopus)

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Schmidt, J. V., Matteson, P. G., Jones, B. K., Guan, X. J. & Tilghman, S. M., Aug 15 2000, In : Genes and Development. 14, 16, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

Genes
Genomic Imprinting
DNA Methylation
1999
81 Citations (Scopus)

Enhancer competition between H19 and Igf2 does not mediate their imprinting

Schmidt, J. V., Levorse, J. M. & Tilghman, S. M., Aug 17 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 17, p. 9733-9738 6 p.

Research output: Contribution to journalArticle

Genes
Genomic Imprinting
Chromosomes, Human, Pair 7
Gene Silencing
Technology
12 Citations (Scopus)

Monoallelic expression of reactivated imprinted genes in embryonal carcinoma cell hybrids

Forejt, J., Saam, J. R., Gregorová, S. & Tilghman, S. M., Nov 1 1999, In : Experimental Cell Research. 252, 2, p. 416-422 7 p.

Research output: Contribution to journalArticle

Embryonal Carcinoma Stem Cells
Lymphocytes
Genes
Hybrid Cells
DNA Methylation
134 Citations (Scopus)

Oppositely imprinted genes p57(Kip2) and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome

Caspary, T., Cleary, M. A., Perlman, E. J., Zhang, P., Elledge, S. J. & Tilghman, S. M., Dec 1 1999, In : Genes and Development. 13, 23, p. 3115-3124 10 p.

Research output: Contribution to journalArticle

Beckwith-Wiedemann Syndrome
Macroglossia
Genes
Mutation
Polydactyly
410 Citations (Scopus)

The sins of the fathers and mothers: Genomic imprinting in mammalian development

Tilghman, S. M., Jan 22 1999, In : Cell. 96, 2, p. 185-193 9 p.

Research output: Contribution to journalReview article

Genomic Imprinting
Fathers
Mothers
268 Citations (Scopus)

The temporal requirement for endothelin receptor-B signalling during neural crest development

Shin, M. K., Levorse, J. M., Ingram, R. S. & Tilghman, S. M., Dec 2 1999, In : Nature. 402, 6761, p. 496-501 6 p.

Research output: Contribution to journalArticle

Endothelin B Receptors
Neural Crest
Embryonic Development
Tetracycline
Megacolon
1998
65 Citations (Scopus)

Chromatin conformation of the H19 epigenetic mark

Hark, A. T. & Tilghman, S. M., Nov 1 1998, In : Human molecular genetics. 7, 12, p. 1979-1985 7 p.

Research output: Contribution to journalArticle

Epigenomics
Chromatin
Chromosomes
Mothers
Genes
17 Citations (Scopus)

Competitive edge at the imprinted Prader-Willi/Angelman region?

Tilghman, S. M., Caspary, T. & Ingram, R. S., Mar 26 1998, In : Nature Genetics. 18, 3, p. 206-208 3 p.

Research output: Contribution to journalReview article

Angelman Syndrome
Small Nuclear Ribonucleoproteins
IGF Type 2 Receptor
Genomic Imprinting
Prader-Willi Syndrome
139 Citations (Scopus)

Genomic imprinting is disrupted in interspecific Peromyscus hybrids

Vrana, P. B., Guan, X. J., Ingram, R. S. & Tilghman, S. M., Dec 8 1998, In : Nature Genetics. 20, 4, p. 362-365 4 p.

Research output: Contribution to journalArticle

Peromyscus
Genomic Imprinting
Alleles
Resource Allocation
Diploidy
85 Citations (Scopus)

Igf2 imprinting does not require its own DNA methylation or H19 RNA

Jones, B. K., Levorse, J. M. & Tilghman, S. M., Jul 15 1998, In : Genes and Development. 12, 14, p. 2200-2207 8 p.

Research output: Contribution to journalArticle

DNA Methylation
Genes
Chromosomes
Mothers
Mutation
107 Citations (Scopus)

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

Webber, A. L., Ingram, R. S., Levorse, J. M. & Tilghman, S. M., Feb 12 1998, In : Nature. 391, 6668, p. 711-715 5 p.

Research output: Contribution to journalArticle

Chromosomes
Mothers
Genes
Genomic Imprinting
Endoderm
34 Citations (Scopus)

Methylation analysis of the PWS/AS region does not support an enhancer- competition model [4]

Schumacher, A., Buiting, K., Zeschnigk, M., Doerfler, W., Horsthemke, B., Tilghman, S. M. & Schoenherr, C. J., Aug 13 1998, In : Nature Genetics. 19, 4, p. 324-325 2 p.

Research output: Contribution to journalLetter

210 Citations (Scopus)

Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster

Caspary, T., Cleary, M. A., Baker, C. C., Guan, X. J. & Tilghman, S. M., Jan 1 1998, In : Molecular and cellular biology. 18, 6, p. 3466-3474 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 7
Multigene Family
Genes
Genomic Imprinting
Gene Deletion