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1972 …2019
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Research Output 1972 2019

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Article
2019
2 Citations (Scopus)

The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells

Lin, K. C., Torga, G., Sun, Y., Axelrod, R., Pienta, K. J., Sturm, J. C. & Austin, R. H., Apr 15 2019, In : Clinical and Experimental Metastasis. 36, 2, p. 97-108 12 p.

Research output: Contribution to journalArticle

docetaxel
Polyploidy
Prostatic Neoplasms
Giant Cells
Neoplasms
2018
3 Citations (Scopus)

A platinum-porphine/poly(perfluoroether) film oxygen tension sensor for noninvasive local monitoring of cellular oxygen metabolism using phosphorescence lifetime imaging

Zhao, Y., Liu, L., Luo, T., Hong, L., Peng, X., Austin, R. H. & Qu, J., Sep 15 2018, In : Sensors and Actuators, B: Chemical. 269, p. 88-95 8 p.

Research output: Contribution to journalArticle

oxygen metabolism
oxygen tension
Phosphorescence
phosphorescence
Platinum
2 Citations (Scopus)

Emergence of Escherichia coli critically buckled motile helices under stress

Phan, T. V., Morris, R. J., Lam, H. T., Hulamm, P., Black, M. E., Bos, J. & Austin, R. H., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 12979-12984 6 p.

Research output: Contribution to journalArticle

Escherichia coli
Bacteria
Phenotype
Microbial Sensitivity Tests
Anti-Bacterial Agents
2017
19 Citations (Scopus)

Broken flow symmetry explains the dynamics of small particles in deterministic lateral displacement arrays

Kim, S. C., Wunsch, B. H., Hu, H., Smith, J. T., Austin, R. H. & Stolovitzky, G., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5034-E5041

Research output: Contribution to journalArticle

Particle Size
Theoretical Models
2 Citations (Scopus)

On-chip cell labelling and washing by capture and release using microfluidic trap arrays

Chen, Y., Austin, R. H. & Sturm, J. C., Sep 1 2017, In : Biomicrofluidics. 11, 5, 054107.

Research output: Contribution to journalArticle

Microfluidics
washing
Washing
Labeling
marking
2016
9 Citations (Scopus)

Automated leukocyte processing by microfluidic deterministic lateral displacement

Civin, C. I., Ward, T., Skelley, A. M., Gandhi, K., Peilun Lee, Z., Dosier, C. R., D'Silva, J. L., Chen, Y., Kim, M. J., Moynihan, J., Chen, X., Aurich, L., Gulnik, S., Brittain, G. C., Recktenwald, D. J., Austin, R. H. & Sturm, J. C., Dec 1 2016, In : Cytometry Part A. 89, 12, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Microfluidics
Leukocytes
Centrifugation
Cell Size
Plastics
7 Citations (Scopus)

How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time

Pedersen, J. N., Li, L., Grǎdinaru, C., Austin, R. H., Cox, E. C. & Flyvbjerg, H., Dec 6 2016, In : Physical Review E. 94, 6, 062401.

Research output: Contribution to journalArticle

Microorganisms
microorganisms
Dynamical Model
Continuous Time
trajectories
111 Citations (Scopus)

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20nm

Wunsch, B. H., Smith, J. T., Gifford, S. M., Wang, C., Brink, M., Bruce, R. L., Austin, R. H., Stolovitzky, G. & Astier, Y., Nov 1 2016, In : Nature Nanotechnology. 11, 11, p. 936-940 5 p.

Research output: Contribution to journalArticle

Colloids
colloids
Blood
Cells
Biopsy
52 Citations (Scopus)

Oriented collagen fibers direct tumor cell intravasation

Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H. & Liu, L., Oct 4 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 40, p. 11208-11213 6 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Collagen
Neoplasms
Breast Neoplasms
Proteins
18 Citations (Scopus)

Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology

Han, J., Jun, Y., Kim, S. H., Hoang, H. H., Jung, Y., Kim, S., Kim, J., Austin, R. H., Lee, S. & Park, S., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14283-14288 6 p.

Research output: Contribution to journalArticle

Microfluidics
Glioblastoma
Ecology
Doxorubicin
Lab-On-A-Chip Devices
2015
18 Citations (Scopus)

Ancient hot and cold genes and chemotherapy resistance emergence

Wu, A., Zhang, Q., Lambert, G., Khin, Z., Gatenby, R. A., Kim, H. J., Pourmand, N., Bussey, K., Davies, P. C. W., Sturm, J. C. & Austin, R. H., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. 10467-10472 6 p.

Research output: Contribution to journalArticle

Drug Therapy
Genes
Doxorubicin
RNA Sequence Analysis
Neoplasms
14 Citations (Scopus)

Concentrating genomic length DNA in a microfabricated array

Chen, Y., Abrams, E. S., Boles, T. C., Pedersen, J. N., Flyvbjerg, H., Austin, R. H. & Sturm, J. C., May 15 2015, In : Physical review letters. 114, 19, 198303.

Research output: Contribution to journalArticle

concentrating
deoxyribonucleic acid
glycols
polyethylenes
shear
50 Citations (Scopus)

Emergence of antibiotic resistance from multinucleated bacterial filaments

Bos, J., Zhang, Q., Vyawahare, S., Rogers, E., Rosenberg, S. M. & Austin, R. H., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 178-183 6 p.

Research output: Contribution to journalArticle

Bacterial Drug Resistance
Ciprofloxacin
Chromosomes
Escherichia coli
Bacteria
3 Citations (Scopus)

Evolutionary game theory in cancer: First steps in prediction of metastatic cancer progression?

Wu, A., Liao, D. & Austin, R. H., Mar 1 2015, In : Future Oncology. 11, 6, p. 881-883 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
Blood Cells
Blood
Processing
Cell Fractionation
Microfluidics
3 Citations (Scopus)

Microfluidic chemical processing with on-chip washing by deterministic lateral displacement arrays with separator walls

Chen, Y., D'Silva, J., Austin, R. H. & Sturm, J. C., Jan 1 2015, In : Biomicrofluidics. 9, 5, 054105.

Research output: Contribution to journalArticle

Microfluidics
washing
Lab-On-A-Chip Devices
separators
Separators
2014
11 Citations (Scopus)

Game theory in the death galaxy: Interaction of cancer and stromal cells in tumour microenvironment

Wu, A., Liao, D., Tlsty, T. D., Sturm, J. C. & Austin, R. H., Aug 6 2014, In : Interface Focus. 4, 4, 20140028.

Research output: Contribution to journalArticle

Galaxies
Game Theory
Tumor Microenvironment
Game theory
Stromal Cells
10 Citations (Scopus)

Physics of biofilms: The initial stages of biofilm formation and dynamics

Lambert, G., Bergman, A., Zhang, Q., Bortz, D. & Austin, R. H., Jan 1 2014, In : New Journal of Physics. 16, 045005.

Research output: Contribution to journalArticle

biofilms
physics
bacteria
physiological responses
antibiotics
22 Citations (Scopus)

Resistance to chemotherapy: Patient variability and cellular heterogeneity

Kessler, D. A., Austin, R. H. & Levine, H., Sep 1 2014, In : Cancer Research. 74, 17, p. 4663-4670 8 p.

Research output: Contribution to journalArticle

Drug Therapy
Multiple Myeloma
Melanoma
Neoplasms
Therapeutics
2013
88 Citations (Scopus)

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

Natural Science Disciplines
Neoplasm Metastasis
Cell Line
Mechanics
Proteomics
47 Citations (Scopus)

Cell motility and drug gradients in the emergence of resistance to chemotherapy

Wu, A., Loutherback, K., Lambert, G., Estéèez-Salmerón, L., Tlsty, T. D., Austin, R. H. & Sturm, J. C., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16103-16108 6 p.

Research output: Contribution to journalArticle

Cell Movement
Doxorubicin
Drug Therapy
Pharmaceutical Preparations
Neoplasms
39 Citations (Scopus)

Minimization of thermodynamic costs in cancer cell invasion

Liu, L., Duclos, G., Sun, B., Lee, J., Wu, A., Kam, Y., Sontag, E. D., Stone, H. A., Sturm, J. C., Gatenby, R. A. & Austin, R. H., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Thermodynamics
Costs and Cost Analysis
Neoplasms
Collagen
Glucose
2012
31 Citations (Scopus)

Applications of Microfluidics in Stem Cell Biology

Zhang, Q. & Austin, R. H., Nov 1 2012, In : BioNanoScience. 2, 4, p. 277-286 10 p.

Research output: Contribution to journalArticle

Cytology
Stem cells
Microfluidics
Tissue culture
Medical applications
122 Citations (Scopus)

Deterministic separation of cancer cells from blood at 10 mL/min

Loutherback, K., D'Silva, J., Liu, L., Wu, A., Austin, R. H. & Sturm, J. C., Dec 1 2012, In : AIP Advances. 2, 4, 042107.

Research output: Contribution to journalArticle

blood
tumors
cancer
flow velocity
microfluidic devices
197 Citations (Scopus)

DNA confinement in nanochannels: Physics and biological applications

Reisner, W., Pedersen, J. N. & Austin, R. H., Oct 1 2012, In : Reports on Progress in Physics. 75, 10, 106601.

Research output: Contribution to journalArticle

deoxyribonucleic acid
physics
genome
molecules
sequencing
9 Citations (Scopus)

Physics of cancer propagation: A game theory perspective

Cleveland, C., Liao, D. & Austin, R. H., Dec 1 2012, In : AIP Advances. 2, 1, 011202.

Research output: Contribution to journalArticle

game theory
cancer
physics
propagation
games
2011
245 Citations (Scopus)

Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments

Zhang, Q., Lambert, G., Liao, D., Kim, H., Robin, K., Tung, C. K., Pourmand, N. & Austin, R. H., Oct 23 2011, In : Science. 333, 6050, p. 1764-1767 4 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Bacterial Drug Resistance
Ciprofloxacin
Microbial Drug Resistance
Drug Resistance
13 Citations (Scopus)

Anomalous spatial redistribution of competing bacteria under starvation conditions

Lambert, G., Liao, D., Vyawahare, S. & Austin, R. H., Apr 1 2011, In : Journal of bacteriology. 193, 8, p. 1878-1883 6 p.

Research output: Contribution to journalArticle

Starvation
Bacteria
Food
Growth
Specific Gravity
21 Citations (Scopus)

Collapse of DNA in ac electric fields

Zhou, C., Reisner, W. W., Staunton, R. J., Ashan, A., Austin, R. H. & Riehn, R., Jun 16 2011, In : Physical review letters. 106, 24, 248103.

Research output: Contribution to journalArticle

deoxyribonucleic acid
electric fields
relaxation time
molecules

Development of an extreme environment materials research facility at princeton

Cohen, A. B., Gentile, C. A., Tully, C. G., Austin, R. H., Calaprice, F., McDonald, K., Ascione, G., Baker, G., Davidson, R., Dudek, L., Grisham, L., Kugel, H., Pagdon, K., Stevenson, T., Woolley, R. & Zwicker, A., Jan 1 2011, In : Fusion Science and Technology. 60, 2, p. 454-458 5 p.

Research output: Contribution to journalArticle

research facilities
neutrons
Neutrons
power lines
high vacuum
29 Citations (Scopus)

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

Liu, L., Sun, B., Pedersen, J. N., Yong, K. M. A., Getzenberg, R. H., Stone, H. A. & Austin, R. H., Apr 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6853-6856 4 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasms
Contact Inhibition
Confocal Microscopy
Breast Neoplasms
12 Citations (Scopus)

The goldilocks principle and antibiotic resistance in bacteria

Zhang, Q., Robin, K., Liao, D., Lambert, G. & Austin, R. H., Dec 5 2011, In : Molecular Pharmaceutics. 8, 6, p. 2063-2068 6 p.

Research output: Contribution to journalArticle

Ciprofloxacin
Microbial Drug Resistance
Escherichia coli
Anti-Bacterial Agents
Bacteria
2010
35 Citations (Scopus)

A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces

Liu, L., Loutherback, K., Liao, D., Yeater, D., Lambert, G., Estévez-Torres, A., Sturm, J. C., Getzenberg, R. H. & Austin, R. H., Jan 1 2010, In : Lab on a Chip. 10, 14, p. 1807-1813 7 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Hydrodynamics
Cell culture
Microfluidics
Cell Culture Techniques
61 Citations (Scopus)

Collective escape of chemotactic swimmers through microscopic ratchets

Lambert, G., Liao, D. & Austin, R. H., Apr 22 2010, In : Physical review letters. 104, 16, 168102.

Research output: Contribution to journalArticle

bacteria
escape
funnels
rectification
inoculation
83 Citations (Scopus)

Improved performance of deterministic lateral displacement arrays with triangular posts

Loutherback, K., Chou, K. S., Newman, J., Puchalla, J., Austin, R. H. & Sturm, J. C., Dec 1 2010, In : Microfluidics and Nanofluidics. 9, 6, p. 1143-1149 7 p.

Research output: Contribution to journalArticle

Hydrostatic pressure
Medicine
Purification
plugging
biology
50 Citations (Scopus)

Particle size dependence of the dynamic photophysical properties of NaYF4:Yb, Er nanocrystals

Lim, S. F., Ryu, W. S. & Austin, R. H., Feb 1 2010, In : Optics Express. 18, 3, p. 2309-2316 8 p.

Research output: Contribution to journalArticle

dynamic characteristics
nanocrystals
decay rates
emission spectra
luminescence
98 Citations (Scopus)

Synthesis of stable block-copolymer-protected NaYF 4:Yb 3+, Er 3+ up-converting phosphor nanoparticles

Budijono, S. J., Shan, J., Yao, N., Miura, Y., Hoye, T., Austin, R. H., Ju, Y. & Prud'homme, R. K., Jan 26 2010, In : Chemistry of Materials. 22, 2, p. 311-318 8 p.

Research output: Contribution to journalArticle

Phosphors
Block copolymers
Nanoparticles
Polyethylene glycols
phosphine
2 Citations (Scopus)

The anti-lotus leaf effect in nanohydrodynamic bump arrays

Morton, K., Tsui, O. K. C., Tung, C. K., Sturm, J. C., Chou, S. Y. & Austin, R. H., Aug 19 2010, In : New Journal of Physics. 12, 085008.

Research output: Contribution to journalArticle

leaves
wetting
sealing
hydraulics
penetration
2009
1 Citation (Scopus)
Nanofluidics
Semiconductors
Oxides
CMOS
Electronic equipment
69 Citations (Scopus)

Deterministic microfluidic ratchet

Loutherback, K., Puchalla, J., Austin, R. H. & Sturm, J. C., Jan 26 2009, In : Physical Review Letters. 102, 4, 045301.

Research output: Contribution to journalArticle

oscillating flow
fluids
low Reynolds number
pressure gradients
velocity distribution
116 Citations (Scopus)

Nanofabricated upconversion nanoparticles for photodynamic therapy

Ungun, B., Prud'homme, R. K., Budijono, S. J., Shan, J., Lim, S. F., Ju, Y. & Austin, R. H., Jan 5 2009, In : Optics Express. 17, 1, p. 80-86 7 p.

Research output: Contribution to journalArticle

therapy
nanoparticles
composite materials
clearances
porphyrins
12 Citations (Scopus)

Tilting after dutch windmills: Probably no long-lived davydov solitons in proteins

Austin, R. H., Xie, A., Fu, D., Warren, W. W., Redlich, B. & Van Der Meer, L., Feb 1 2009, In : Journal of Biological Physics. 35, 1, p. 91-101 11 p.

Research output: Contribution to journalArticle

myoglobin
Myoglobin
Amides
amides
solitary waves
56 Citations (Scopus)

Upconverting nanophosphors for bioimaging

Lim, S. F., Riehn, R., Tung, C. K., Ryu, W. S., Zhuo, R., Dalland, J. & Austin, R. H., Oct 12 2009, In : Nanotechnology. 20, 40, 405701.

Research output: Contribution to journalArticle

Nanoparticles
Photons
Infrared radiation
Amines
Excitation energy
2008
10 Citations (Scopus)
Spectrum Analysis
Chaperonins
Ribulose-Bisphosphate Carboxylase
Macromolecular Substances
Oxygenases
43 Citations (Scopus)

Computation of mutual fitness by competing bacteria

Keymer, J. E., Galajda, P., Lambert, G., Liao, D. & Austin, R. H., Dec 23 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 51, p. 20269-20273 5 p.

Research output: Contribution to journalArticle

Population Dynamics
Population Growth
Bacteria
Growth
Salaries and Fringe Benefits
82 Citations (Scopus)

Crossing microfluidic streamlines to lyse, label and wash cells

Morton, K. J., Loutherback, K., Inglis, D. W., Tsui, O. K., Sturm, J. C., Chou, S. Y. & Austin, R. H., Jan 1 2008, In : Lab on a Chip. 8, 9, p. 1448-1453 6 p.

Research output: Contribution to journalArticle

Microfluidics
Washing
Labels
Chemical operations
Labeling
44 Citations (Scopus)

Determining blood cell size using microfluidic hydrodynamics

Inglis, D. W., Davis, J. A., Zieziulewicz, T. J., Lawrence, D. A., Austin, R. H. & Sturm, J. C., Jan 1 2008, In : Journal of Immunological Methods. 329, 1-2, p. 151-156 6 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Microfluidics
Hydrodynamics
Cell Size
Blood Cells
85 Citations (Scopus)

Enhanced Caenorhabditis elegans locomotion in a structured microfluidic environment

Park, S., Hwang, H., Nam, S. W., Martinez, F., Austin, R. H. & Ryu, W. S., Aug 25 2008, In : PloS one. 3, 6, e2550.

Research output: Contribution to journalArticle

Microfluidics
Caenorhabditis elegans
Locomotion
microstructure
locomotion
25 Citations (Scopus)

Funnel ratchets in biology at low Reynolds number: Choanotaxis

Galajda, P., Keymer, J., Dalland, J., Park, S., Kou, S. & Austin, R. H., Nov 1 2008, In : Journal of Modern Optics. 55, 19-20, p. 3413-3422 10 p.

Research output: Contribution to journalArticle

funnels
low Reynolds number
biology
bacteria
interactions
74 Citations (Scopus)

Hydrodynamic metamaterials: Microfabricated arrays to steer, refract, and focus streams of biomaterials

Morton, K. J., Loutherback, K., Inglis, D. W., Tsui, O. K., Sturm, J. C., Chou, S. Y. & Austin, R. H., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7434-7438 5 p.

Research output: Contribution to journalArticle

Microfluidics
Biocompatible Materials
Hydrodynamics
Light
Photons