• 17539 Citations
  • 70 h-Index
1972 …2019
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Research Output 1972 2019

2019

Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance

Amend, S. R., Torga, G., Lin, K. C., Kostecka, L. G., de Marzo, A., Austin, R. H. & Pienta, K. J., Jan 1 2019, In : Prostate. 79, 13, p. 1489-1497 9 p.

Research output: Contribution to journalReview article

Polyploidy
Giant Cells
Carcinogenesis
Neoplasm Metastasis
Neoplasms
2 Citations (Scopus)

The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells

Lin, K. C., Torga, G., Sun, Y., Axelrod, R., Pienta, K. J., Sturm, J. C. & Austin, R. H., Apr 15 2019, In : Clinical and Experimental Metastasis. 36, 2, p. 97-108 12 p.

Research output: Contribution to journalArticle

docetaxel
Polyploidy
Prostatic Neoplasms
Giant Cells
Neoplasms
2018
1 Citation (Scopus)

A bacterial antibiotic resistance accelerator and applications

Bos, J. & Austin, R. H., Jan 1 2018, Methods in Cell Biology. Piel, M., Fletcher, D. & Doh, J. (eds.). Academic Press Inc., p. 41-57 17 p. (Methods in Cell Biology; vol. 147).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacterial Drug Resistance
Anti-Bacterial Agents
Drug Resistance
Population
Bacteria
3 Citations (Scopus)

A platinum-porphine/poly(perfluoroether) film oxygen tension sensor for noninvasive local monitoring of cellular oxygen metabolism using phosphorescence lifetime imaging

Zhao, Y., Liu, L., Luo, T., Hong, L., Peng, X., Austin, R. H. & Qu, J., Sep 15 2018, In : Sensors and Actuators, B: Chemical. 269, p. 88-95 8 p.

Research output: Contribution to journalArticle

oxygen metabolism
oxygen tension
Phosphorescence
phosphorescence
Platinum
2 Citations (Scopus)

Emergence of Escherichia coli critically buckled motile helices under stress

Phan, T. V., Morris, R. J., Lam, H. T., Hulamm, P., Black, M. E., Bos, J. & Austin, R. H., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 12979-12984 6 p.

Research output: Contribution to journalArticle

Escherichia coli
Bacteria
Phenotype
Microbial Sensitivity Tests
Anti-Bacterial Agents
2017
19 Citations (Scopus)

Broken flow symmetry explains the dynamics of small particles in deterministic lateral displacement arrays

Kim, S. C., Wunsch, B. H., Hu, H., Smith, J. T., Austin, R. H. & Stolovitzky, G., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5034-E5041

Research output: Contribution to journalArticle

Particle Size
Theoretical Models
3 Citations (Scopus)

Cancer biology still needs physicists

Austin, R. H., Oct 24 2017, In : Nature. 550, 7677, 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

On-chip cell labelling and washing by capture and release using microfluidic trap arrays

Chen, Y., Austin, R. H. & Sturm, J. C., Sep 1 2017, In : Biomicrofluidics. 11, 5, 054107.

Research output: Contribution to journalArticle

Microfluidics
washing
Washing
Labeling
marking
2016
9 Citations (Scopus)

Automated leukocyte processing by microfluidic deterministic lateral displacement

Civin, C. I., Ward, T., Skelley, A. M., Gandhi, K., Peilun Lee, Z., Dosier, C. R., D'Silva, J. L., Chen, Y., Kim, M. J., Moynihan, J., Chen, X., Aurich, L., Gulnik, S., Brittain, G. C., Recktenwald, D. J., Austin, R. H. & Sturm, J. C., Dec 1 2016, In : Cytometry Part A. 89, 12, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Microfluidics
Leukocytes
Centrifugation
Cell Size
Plastics
7 Citations (Scopus)

How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time

Pedersen, J. N., Li, L., Grǎdinaru, C., Austin, R. H., Cox, E. C. & Flyvbjerg, H., Dec 6 2016, In : Physical Review E. 94, 6, 062401.

Research output: Contribution to journalArticle

Microorganisms
microorganisms
Dynamical Model
Continuous Time
trajectories
111 Citations (Scopus)

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20nm

Wunsch, B. H., Smith, J. T., Gifford, S. M., Wang, C., Brink, M., Bruce, R. L., Austin, R. H., Stolovitzky, G. & Astier, Y., Nov 1 2016, In : Nature Nanotechnology. 11, 11, p. 936-940 5 p.

Research output: Contribution to journalArticle

Colloids
colloids
Blood
Cells
Biopsy
52 Citations (Scopus)

Oriented collagen fibers direct tumor cell intravasation

Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H. & Liu, L., Oct 4 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 40, p. 11208-11213 6 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Collagen
Neoplasms
Breast Neoplasms
Proteins
18 Citations (Scopus)

Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology

Han, J., Jun, Y., Kim, S. H., Hoang, H. H., Jung, Y., Kim, S., Kim, J., Austin, R. H., Lee, S. & Park, S., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14283-14288 6 p.

Research output: Contribution to journalArticle

Microfluidics
Glioblastoma
Ecology
Doxorubicin
Lab-On-A-Chip Devices
2015
18 Citations (Scopus)

Ancient hot and cold genes and chemotherapy resistance emergence

Wu, A., Zhang, Q., Lambert, G., Khin, Z., Gatenby, R. A., Kim, H. J., Pourmand, N., Bussey, K., Davies, P. C. W., Sturm, J. C. & Austin, R. H., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. 10467-10472 6 p.

Research output: Contribution to journalArticle

Drug Therapy
Genes
Doxorubicin
RNA Sequence Analysis
Neoplasms
14 Citations (Scopus)

Concentrating genomic length DNA in a microfabricated array

Chen, Y., Abrams, E. S., Boles, T. C., Pedersen, J. N., Flyvbjerg, H., Austin, R. H. & Sturm, J. C., May 15 2015, In : Physical review letters. 114, 19, 198303.

Research output: Contribution to journalArticle

concentrating
deoxyribonucleic acid
glycols
polyethylenes
shear
50 Citations (Scopus)

Emergence of antibiotic resistance from multinucleated bacterial filaments

Bos, J., Zhang, Q., Vyawahare, S., Rogers, E., Rosenberg, S. M. & Austin, R. H., Jan 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 178-183 6 p.

Research output: Contribution to journalArticle

Bacterial Drug Resistance
Ciprofloxacin
Chromosomes
Escherichia coli
Bacteria
3 Citations (Scopus)

Evolutionary game theory in cancer: First steps in prediction of metastatic cancer progression?

Wu, A., Liao, D. & Austin, R. H., Mar 1 2015, In : Future Oncology. 11, 6, p. 881-883 3 p.

Research output: Contribution to journalArticle

Hidden harmonic quantum states in proteins: Did Davydov get the sign wrong?

Xie, A., Redlich, B., Meer, L. V. D., Vyawahare, S. & Austin, R. H., Oct 7 2015, In : Physica Scripta. 2015, T165, 014042.

Research output: Contribution to journalConference article

Quantum State
amides
Harmonic
Scattering
proteins
17 Citations (Scopus)
Blood Cells
Blood
Processing
Cell Fractionation
Microfluidics
3 Citations (Scopus)

Microfluidic chemical processing with on-chip washing by deterministic lateral displacement arrays with separator walls

Chen, Y., D'Silva, J., Austin, R. H. & Sturm, J. C., Jan 1 2015, In : Biomicrofluidics. 9, 5, 054105.

Research output: Contribution to journalArticle

Microfluidics
washing
Lab-On-A-Chip Devices
separators
Separators

Upconverting nanoparticle-based multi-functional nanoplatform for enhanced photodynamic therapy: Promises and perils

Lim, S. F. & Austin, R. H., Feb 3 2015, Applications of Nanoscience in Photomedicine. Elsevier Inc., p. 377-391 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Photochemotherapy
Nanoparticles
Singlet Oxygen
Light
Semiconductor Lasers
2014
15 Citations (Scopus)

Bacteria and game theory: The rise and fall of cooperation in spatially heterogeneous environments

Lambert, G., Vyawahare, S. & Austin, R. H., Aug 6 2014, In : Interface Focus. 4, 4

Research output: Contribution to journalReview article

Game Theory
Game theory
Bacteria
Escherichia coli
Cooperative Behavior

Beyond evolution: Game theory and the progression of cancer

Austin, R. H., Aug 6 2014, In : Interface Focus. 4, 4, 20140044.

Research output: Contribution to journalEditorial

Game Theory
Game theory
Neoplasms
11 Citations (Scopus)

Game theory in the death galaxy: Interaction of cancer and stromal cells in tumour microenvironment

Wu, A., Liao, D., Tlsty, T. D., Sturm, J. C. & Austin, R. H., Aug 6 2014, In : Interface Focus. 4, 4, 20140028.

Research output: Contribution to journalArticle

Galaxies
Game Theory
Tumor Microenvironment
Game theory
Stromal Cells
4 Citations (Scopus)

In vitro microbial culture models and their application in drug development

Vyawahare, S., Zhang, Q., Lau, A. & Austin, R. H., Jan 1 2014, In : Advanced Drug Delivery Reviews. 69-70, p. 217-224 8 p.

Research output: Contribution to journalReview article

Drug Resistance
Lab-On-A-Chip Devices
Bacterial Drug Resistance
Pharmaceutical Preparations
Microtechnology
10 Citations (Scopus)

Physics of biofilms: The initial stages of biofilm formation and dynamics

Lambert, G., Bergman, A., Zhang, Q., Bortz, D. & Austin, R. H., Jan 1 2014, In : New Journal of Physics. 16, 045005.

Research output: Contribution to journalArticle

biofilms
physics
bacteria
physiological responses
antibiotics
7 Citations (Scopus)

Ratchets in hydrodynamic flow: More than waterwheels

Sturm, J. C., Cox, E. C., Comella, B. & Austin, R. H., Dec 6 2014, In : Interface Focus. 4, 6, 20140054.

Research output: Contribution to journalReview article

Microfluidics
Physics
Hydrodynamics
Biotechnology
Mechanics
2 Citations (Scopus)

Rejoice in the hubris: Useful things biologists could do for physicists

Austin, R. H., Oct 1 2014, In : Physical Biology. 11, 5, 053015.

Research output: Contribution to journalReview article

Lions
Socialization
Light
Drive
22 Citations (Scopus)

Resistance to chemotherapy: Patient variability and cellular heterogeneity

Kessler, D. A., Austin, R. H. & Levine, H., Sep 1 2014, In : Cancer Research. 74, 17, p. 4663-4670 8 p.

Research output: Contribution to journalArticle

Drug Therapy
Multiple Myeloma
Melanoma
Neoplasms
Therapeutics
2013
88 Citations (Scopus)

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

Natural Science Disciplines
Neoplasm Metastasis
Cell Line
Mechanics
Proteomics
47 Citations (Scopus)

Cell motility and drug gradients in the emergence of resistance to chemotherapy

Wu, A., Loutherback, K., Lambert, G., Estéèez-Salmerón, L., Tlsty, T. D., Austin, R. H. & Sturm, J. C., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16103-16108 6 p.

Research output: Contribution to journalArticle

Cell Movement
Doxorubicin
Drug Therapy
Pharmaceutical Preparations
Neoplasms
39 Citations (Scopus)

Minimization of thermodynamic costs in cancer cell invasion

Liu, L., Duclos, G., Sun, B., Lee, J., Wu, A., Kam, Y., Sontag, E. D., Stone, H. A., Sturm, J. C., Gatenby, R. A. & Austin, R. H., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Thermodynamics
Costs and Cost Analysis
Neoplasms
Collagen
Glucose
1 Citation (Scopus)
genome
Genomic Instability
Information Storage and Retrieval
Information retrieval
animals
2012
31 Citations (Scopus)

Applications of Microfluidics in Stem Cell Biology

Zhang, Q. & Austin, R. H., Nov 1 2012, In : BioNanoScience. 2, 4, p. 277-286 10 p.

Research output: Contribution to journalArticle

Cytology
Stem cells
Microfluidics
Tissue culture
Medical applications
122 Citations (Scopus)

Deterministic separation of cancer cells from blood at 10 mL/min

Loutherback, K., D'Silva, J., Liu, L., Wu, A., Austin, R. H. & Sturm, J. C., Dec 1 2012, In : AIP Advances. 2, 4, 042107.

Research output: Contribution to journalArticle

blood
tumors
cancer
flow velocity
microfluidic devices
197 Citations (Scopus)

DNA confinement in nanochannels: Physics and biological applications

Reisner, W., Pedersen, J. N. & Austin, R. H., Oct 1 2012, In : Reports on Progress in Physics. 75, 10, 106601.

Research output: Contribution to journalArticle

deoxyribonucleic acid
physics
genome
molecules
sequencing

Free energies, landscapes, and fitness in evolution dynamics

Austin, R. H., Jan 1 2012, Quantitative Biology: From Molecular to Cellular Systems. CRC Press, p. 1-21 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

fitness
polymorphism
nucleotides
Polymorphism
bacteria

Peak-tracking chip" (PTC) for bulk refractive index sensing and bioarray sensing

Bougot-Robin, K., Li, S., Zhang, Y., Kodzius, R., Hsing, I. M., Benisty, H., Austin, R. H. & Wen, W., Jan 1 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 1324-1326 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Refractive index
Waveguides
Fluidics
Surface plasmon resonance
Biomolecules
20 Citations (Scopus)

Physics of cancer: The impact of heterogeneity

Zhang, Q. & Austin, R. H., Feb 27 2012, In : Annual Review of Condensed Matter Physics. 3, 1, p. 363-382 20 p.

Research output: Contribution to journalReview article

Cell growth
Tumors
Physics
cancer
Cells
9 Citations (Scopus)

Physics of cancer propagation: A game theory perspective

Cleveland, C., Liao, D. & Austin, R. H., Dec 1 2012, In : AIP Advances. 2, 1, 011202.

Research output: Contribution to journalArticle

game theory
cancer
physics
propagation
games
1 Citation (Scopus)

Preface: Physics of cancer

Austin, R. H. & Gerstman, B. S., Dec 1 2012, In : AIP Advances. 2, 1, 010901.

Research output: Contribution to journalEditorial

cancer
physics
2011
245 Citations (Scopus)

Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments

Zhang, Q., Lambert, G., Liao, D., Kim, H., Robin, K., Tung, C. K., Pourmand, N. & Austin, R. H., Oct 23 2011, In : Science. 333, 6050, p. 1764-1767 4 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Bacterial Drug Resistance
Ciprofloxacin
Microbial Drug Resistance
Drug Resistance

Acceleration of the emergence of bacterial antibiotic resistance

Zhang, Q., Liao, D. & Austin, R. H., Dec 1 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. p. 1481-1483 3 p. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Antibiotics
Microfluidics
Escherichia coli
Bacteria
100 Citations (Scopus)

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

Lambert, G., Estévez-Salmeron, L., Oh, S., Liao, D., Emerson, B. M., Tlsty, T. D. & Austin, R. H., May 1 2011, In : Nature Reviews Cancer. 11, 5, p. 375-382 8 p.

Research output: Contribution to journalReview article

Bacterial Drug Resistance
Clonal Evolution
Growth
Drug Resistance
Neoplasms
13 Citations (Scopus)

Anomalous spatial redistribution of competing bacteria under starvation conditions

Lambert, G., Liao, D., Vyawahare, S. & Austin, R. H., Apr 1 2011, In : Journal of bacteriology. 193, 8, p. 1878-1883 6 p.

Research output: Contribution to journalArticle

Starvation
Bacteria
Food
Growth
Specific Gravity
21 Citations (Scopus)

Collapse of DNA in ac electric fields

Zhou, C., Reisner, W. W., Staunton, R. J., Ashan, A., Austin, R. H. & Riehn, R., Jun 16 2011, In : Physical review letters. 106, 24, 248103.

Research output: Contribution to journalArticle

deoxyribonucleic acid
electric fields
relaxation time
molecules
Fractionation
Electrophoresis
DNA

Development of an extreme environment materials research facility at princeton

Cohen, A. B., Gentile, C. A., Tully, C. G., Austin, R. H., Calaprice, F., McDonald, K., Ascione, G., Baker, G., Davidson, R., Dudek, L., Grisham, L., Kugel, H., Pagdon, K., Stevenson, T., Woolley, R. & Zwicker, A., Jan 1 2011, In : Fusion Science and Technology. 60, 2, p. 454-458 5 p.

Research output: Contribution to journalArticle

research facilities
neutrons
Neutrons
power lines
high vacuum

Editorial: Welcome to AIP Advances-a new open-access journal from the American Institute of Physics

Austin, R. H., Crespi, V. H., Johnson, A. T. C., Tanaka, M. & Wang, E. G., Sep 20 2011, In : AIP Advances. 1, 1, 010401.

Research output: Contribution to journalEditorial

physics