• 14172 Citations
  • 68 h-Index
1969 …2020

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2020

A Kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids

Scherer, J., Hogue, I. B., Yaffe, Z. A., Tanneti, N. S., Winer, B. Y., Vershinin, M. & Enquist, L. W., 2020, In : PLoS pathogens. 16, 1, e1007985.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Introduction: A New Coronavirus Emerges, This Time Causing a Pandemic

DiMaio, D., Enquist, L. W. & Dermody, T. S., Apr 21 2020, (Accepted/In press) In : Annual review of virology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Invasion of the nervous system

Koyuncu, O. O., Enquist, L. W. & Engel, E. A., 2020, In : Current Issues in Molecular Biology. 41, p. 1-62 62 p.

Research output: Contribution to journalArticle

Open Access

Mouse footpad inoculation model to study viral-induced neuroinflammatory responses

Laval, K., Maturana, C. J. & Enquist, L. W., Jun 2020, In : Journal of Visualized Experiments. 2020, 160, p. 1-15 15 p., e61121.

Research output: Contribution to journalArticle

Pseudorabies virus infection accelerates degradation of the kinesin-3 motor KIF1A

Huang, H., Koyuncu, O. O. & Enquist, L. W., May 1 2020, In : Journal of virology. 94, 9, e01934-19.

Research output: Contribution to journalArticle

3 Scopus citations

Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNS

Maturana, C. J., Verpeut, J. L., Pisano, T. J., Dhanerawala, Z. M., Esteves, A., Enquist, L. W. & Engel, E. A., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 843-857 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type i IFN signaling

Laval, K., Van Cleemput, J., Vernejoul, J. B. & Enquist, L. W., 2019, In : PLoS pathogens. 15, 11, e1008087.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Intranasal leptin relieves sleep-disordered breathing in mice with diet-induced obesity

Berger, S., Pho, H., Fleury-Curado, T., Bevans-Fonti, S., Younas, H., Shin, M. K., Jun, J. C., Anokye-Danso, F., Ahima, R. S., Enquist, L. W., Mendelowitz, D., Schwartz, A. R. & Polotsky, V. Y., Mar 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 6, p. 773-783 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Characterization of the neuroinvasive profile of a pseudorabies virus recombinant expressing the mTurquoise2 reporter in single and multiple injection experiments

Hogue, I. B., Card, J. P., Rinaman, L., Staniszewska Goraczniak, H. & Enquist, L. W., Oct 1 2018, In : Journal of Neuroscience Methods. 308, p. 228-239 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional carboxy-terminal fluorescent protein fusion to pseudorabies virus small capsid protein VP26

Hogue, I. B., Jean, J., Esteves, A. D., Tanneti, N. S., Scherer, J. & Enquist, L. W., Jan 1 2018, In : Journal of virology. 92, 1, e01193-17.

Research output: Contribution to journalArticle

5 Scopus citations

Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons

MacGibeny, M. A., Koyuncu, O. O., Wirblich, C., Schnell, M. J. & Enquist, L. W., Jul 2018, In : PLoS pathogens. 14, 7, e1007188.

Research output: Contribution to journalArticle

13 Scopus citations

Virulent pseudorabies virus infection induces a specific and lethal systemic inflammatory response in mice

Laval, K., Vernejoul, J. B., Van Cleemput, J., Koyuncu, O. O. & Enquist, L. W., Dec 1 2018, In : Journal of virology. 92, 24, e0161418.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing

Koyuncu, O. O., MacGibeny, M. A., Hogue, I. B. & Enquist, L. W., Oct 2017, In : PLoS pathogens. 13, 10, e1006608.

Research output: Contribution to journalArticle

13 Scopus citations

Gene expression profiling with cre-conditional pseudorabies virus reveals a subset of midbrain neurons that participate in reward circuitry

Pomeranz, L. E., Ekstrand, M. I., Latcha, K. N., Smith, G. A., Enquist, L. W. & Friedman, J. M., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4128-4144 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Intrinsic and innate defenses of neurons: Détente with the herpesviruses

Enquist, L. W. & Leib, D. A., 2017, In : Journal of virology. 91, 1, e01200-16.

Research output: Contribution to journalArticle

14 Scopus citations

Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix

Harris, G. M., Madigan, N. N., Lancaster, K. Z., Enquist, L. W., Windebank, A. J., Schwartz, J. & Schwarzbauer, J. E., Jul 1 2017, In : Matrix Biology. 60-61, p. 176-189 14 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

3D printed nervous system on a chip

Johnson, B. N., Lancaster, K. Z., Hogue, I. B., Meng, F., Kong, Y. L., Enquist, L. W. & McAlpine, M. C., Apr 21 2016, In : Lab on a Chip. 16, 8, p. 1393-1400 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Defensive perimeter in the central nervous system: Predominance of astrocytes and astrogliosis during recovery from varicella-zoster virus encephalitis

Carpenter, J. E., Clayton, A. C., Halling, K. C., Bonthius, D. J., Buckingham, E. M., Jackson, W., Dotzler, S. M., Card, J. P., Enquist, L. W. & Grose, C., 2016, In : Journal of virology. 90, 1, p. 379-391 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dual-color herpesvirus capsids discriminate inoculum from progeny and reveal axonal transport dynamics

Scherer, J., Yaffe, Z. A., Vershinin, M. & Enquist, L. W., 2016, In : Journal of virology. 90, 21, p. 9997-10006 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Exocytosis of alphaherpesvirus virions, light particles, and glycoproteins uses constitutive secretory mechanisms

Hogue, I. B., Scherer, J. & Enquist, L. W., 2016, In : mBio. 7, 3, e00820-16.

Research output: Contribution to journalArticle

24 Scopus citations

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

78 Scopus citations

The brain-to-pancreatic islet neuronal map reveals differential glucose regulation from distinct hypothalamic regions

Rosario, W., Singh, I., Wautlet, A., Patterson, C., Flak, J., Becker, T. C., Ali, A., Tamarina, N., Philipson, L. H., Enquist, L. W., Myers, M. G. & Rhodes, C. J., Sep 1 2016, In : Diabetes. 65, 9, p. 2711-2723 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane

Bosse, J. B. & Enquist, L. W., Mar 1 2016, In : Nucleus. 7, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Two modes of the axonal interferon response limit alphaherpesvirus neuroinvasion

Song, R., Koyuncu, O. O., Greco, T. M., Diner, B. A., Cristea, I. M. & Enquist, L. W., Feb 2 2016, In : mBio. 7, 1, e02145-15.

Research output: Contribution to journalArticle

25 Scopus citations

What Have We Done for You Lately? The Role of the American Society for Microbiology in Advancing Clinical Microbiology

Sharp, S. E. & Enquist, L. W., Jun 15 2016, In : Clinical Microbiology Newsletter. 38, 12, p. 95-100 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

3D Printed Anatomical Nerve Regeneration Pathways

Johnson, B. N., Lancaster, K. Z., Zhen, G., He, J., Gupta, M. K., Kong, Y. L., Engel, E. A., Krick, K. D., Ju, A., Meng, F., Enquist, L. W., Jia, X. & McAlpine, M. C., Oct 1 2015, In : Advanced Functional Materials. 25, 39, p. 6205-6217 13 p.

Research output: Contribution to journalArticle

127 Scopus citations

Open LED illuminator: A simple and inexpensive LED illuminator for fast multicolor particle tracking in neurons

Bosse, J. B., Tanneti, N. S., Hogue, I. B. & Enquist, L. W., Nov 1 2015, In : PloS one. 10, 11, e0143547.

Research output: Contribution to journalArticle

6 Scopus citations

Rapid genome assembly and comparison decode intrastrain variation in human alphaherpesviruses

Parsons, L. R., Tafuri, Y. R., Shreve, J. T., Bowen, C. D., Shipley, M. M., Enquist, L. W. & Szpara, M. L., Mar 31 2015, In : mBio. 6, 2, e02213-14.

Research output: Contribution to journalArticle

20 Scopus citations

Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion

Bosse, J. B., Hogue, I. B., Feric, M., Thiberge, S. Y., Sodeik, B., Brangwynne, C. P. & Enquist, L. W., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5752-E5733

Research output: Contribution to journalArticle

27 Scopus citations

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane

Hagen, C., Dent, K. C., Zeev-Ben-Mordehai, T., Grange, M., Bosse, J. B., Whittle, C., Klupp, B. G., Siebert, C. A., Vasishtan, D., Bäuerlein, F. J. B., Cheleski, J., Werner, S., Guttmann, P., Rehbein, S., Henzler, K., Demmerle, J., Adler, B., Koszinowski, U., Schermelleh, L., Schneider, G. & 4 others, Enquist, L. W., Plitzko, J. M., Mettenleiter, T. C. & Grünewald, K., Dec 17 2015, In : Cell. 163, 7, p. 1692-1701 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

The neuroinvasive profiles of H129 (herpes simplex virus type 1) recombinants with putative anterograde-only transneuronal spread properties

Wojaczynski, G. J., Engel, E. A., Steren, K. E., Enquist, L. W. & Patrick Card, J., May 1 2015, In : Brain Structure and Function. 220, 3, p. 1395-1420 26 p.

Research output: Contribution to journalArticle

30 Scopus citations

The number of alphaherpesvirus particles infecting axons and the axonal protein repertoire determines the outcome of neuronal infection

Koyuncu, O. O., Song, R., Greco, T. M., Cristea, I. M. & Enquist, L. W., Mar 24 2015, In : mBio. 6, 2, e00276-15.

Research output: Contribution to journalArticle

21 Scopus citations

Us9-independent axonal sorting and transport of the pseudorabies virus glycoprotein gM

Kratchmarov, R., Enquist, L. W. & Taylor, M. P., 2015, In : Journal of virology. 89, 12, p. 6511-6514 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Cellular Mechanisms of Alpha Herpesvirus Egress: Live Cell Fluorescence Microscopy of Pseudorabies Virus Exocytosis

Hogue, I. B., Bosse, J. B., Hu, J. R., Thiberge, S. Y. & Enquist, L. W., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

45 Scopus citations

Characterization of a replication-incompetent pseudorabies virus mutant lacking the sole immediate early gene IE180

Wu, B. W., Engel, E. A. & Enquist, L. W., Sep 25 2014, In : mBio. 5, 6, e01850-14.

Research output: Contribution to journalArticle

13 Scopus citations

Evolution and diversity in human herpes simplex virus genomes

Szpara, M. L., Gatherer, D., Ochoa, A., Greenbaum, B., Dolan, A., Bowden, R. J., Enquist, L. W., Legendre, M. & Davison, A. J., Jan 2014, In : Journal of virology. 88, 2, p. 1209-1227 19 p.

Research output: Contribution to journalArticle

102 Scopus citations

Genome sequence of the anterograde-spread-defective herpes simplex virus 1 strain MacIntyre

Szpara, M. L., Tafuri, Y. R., Parsons, L., Shreve, J. T., Engel, E. A. & Enquist, L. W., 2014, In : Genome Announcements. 2, 6, e01161-14.

Research output: Contribution to journalArticle

7 Scopus citations

Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus

Oyibo, H. K., Znamenskiy, P., Oviedo, H. V., Enquist, L. W. & Zador, A. M., Sep 3 2014, In : Frontiers in Neuroanatomy. 8, SEP, 86.

Research output: Contribution to journalArticle

31 Scopus citations

Nuclear herpesvirus capsid motility is not dependent on F-Actin

Bosse, J. B., Virding, S., Thiberge, S. Y., Scherer, J., Wodrich, H., Ruzsics, Z., Koszinowski, U. H. & Enquist, L. W., Oct 7 2014, In : mBio. 5, 5, e01909-14.

Research output: Contribution to journalArticle

21 Scopus citations

Transneuronal circuit analysis with pseudorabies viruses

Card, J. P. & Enquist, L. W., 2014, In : Current Protocols in Neuroscience. SUPP.68, 1.5.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Efficient retrograde transport of pseudorabies virus within neurons requires local protein synthesis in axons

Koyuncu, O. O., Perlman, D. H. & Enquist, L. W., Jan 16 2013, In : Cell Host and Microbe. 13, 1, p. 54-66 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Fast GCaMPs for improved tracking of neuronal activity

Sun, X. R., Badura, A., Pacheco, D. A., Lynch, L. A., Schneider, E. R., Taylor, M. P., Hogue, I. B., Enquist, L. W., Murthy, M. & Wang, S. S. H., Jul 18 2013, In : Nature communications. 4, 2170.

Research output: Contribution to journalArticle

73 Scopus citations

Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons

Kratchmarov, R., Kramer, T., Greco, T. M., Taylor, M. P., Ch'ng, T. H., Cristea, I. M. & Enquist, L. W., 2013, In : Journal of virology. 87, 17, p. 9431-9440 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Imaging the transport dynamics of single alphaherpesvirus particles in intact peripheral nervous system explants from infected mice

Granstedt, A. E., Brunton, B. W. & Enquist, L. W., 2013, In : mBio. 4, 3, e00358-13.

Research output: Contribution to journalArticle

14 Scopus citations

In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins

Granstedt, A. E., Bosse, J. B., Thiberge, S. Y. & Enquist, L. W., Sep 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. E3516-E3525

Research output: Contribution to journalArticle

18 Scopus citations

Live cell imaging of alphaherpes virus anterograde transport and spread

Taylor, M. P., Kratchmarov, R. & Enquist, L. W., 2013, In : Journal of visualized experiments : JoVE. 78

Research output: Contribution to journalArticle

1 Scopus citations

Live cell imaging of alphaherpes virus anterograde transport and spread.

Taylor, M. P., Kratchmarov, R. & Enquist, L. W., 2013, In : Journal of visualized experiments : JoVE. 78

Research output: Contribution to journalArticle

11 Scopus citations

Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus

Kratchmarov, R., Taylor, M. P. & Enquist, L. W., Mar 19 2013, In : PloS one. 8, 3, e58776.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Alphaherpesvirus axon-to-cell spread involves limited virion transmission

Taylor, M. P., Kobiler, O. & Enquist, L. W., Oct 16 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 17046-17051 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Alphaherpesvirus infection disrupts mitochondrial transport in neurons

Kramer, T. & Enquist, L. W., May 17 2012, In : Cell Host and Microbe. 11, 5, p. 504-514 11 p.

Research output: Contribution to journalArticle

43 Scopus citations