Joshua Akey
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Joshua Akey

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1997 …2023

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  • 2023

    Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project

    Dog Aging Project Consortium, Apr 2023, In: GeroScience. 45, 2, p. 645-661 17 p.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations
  • 2022

    Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers

    Saha, S., Khan, N., Comi, T., Verhagen, A., Sasmal, A., Diaz, S., Yu, H., Chen, X., Akey, J. M., Frank, M., Gagneux, P. & Varki, A., Aug 1 2022, In: Molecular biology and evolution. 39, 8, msac151.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project

    Dog Aging Project Consortium, Jun 2022, In: GeroScience. 44, 3, p. 1779-1790 12 p.

    Research output: Contribution to journal › Article › peer-review

    8 Scopus citations

  • Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank

    Mouttham, L., Castelhano, M. G., Akey, J. M., Benton, B., Borenstein, E., Castelhano, M. G., Coleman, A. E., Creevy, K. E., Crowder, K., Dunbar, M. D., Ernst, H. R., Fajt, V. R., Fitzpatrick, A. L., Garrison, S. J., Herndon, R. S., Jaramilla, D., Jeffery, U., Jonlin, E. C., Kaeberlein, M., Karlsson, E. K., & 14 othersKerr, K. F., Levine, J. M., Ma, J., McClelland, R. L., Prescott, J. O., Promislow, D. E. L., Ruple, A., Schwartz, S. M., Shrager, S., Snyder-Mackler, N., Tinkle, A. K., Tolbert, M. K., Urfer, S. R. & Wilfond, B. S., Jan 1 2022, In: Biomarker Insights. 17

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2021

    Deep sequencing of 1320 genes reveals the landscape of protein-truncating variants and their contribution to psoriasis in 19,973 Chinese individuals

    Xu, H., Zhen, Q., Bai, M., Fang, L., Zhang, Y., Li, B., Ge, H., Moon, S., Chen, W., Fu, W., Xu, Q., Zhou, Y., Yu, Y., Lin, L., Yong, L., Zhang, T., Chen, S., Liu, S., Zhang, H., Chen, R., & 8 othersCao, L., Zhang, Y., Zhang, R., Yang, H., Hu, X., Akey, J. M., Jin, X. & Sun, L., Jul 2021, In: Genome Research. 31, 7, p. 1150-1158 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

    GTEx Consortium, May 13 2021, In: Cell. 184, 10, p. 2633-2648.e19

    Research output: Contribution to journal › Article › peer-review

    Open Access
    59 Scopus citations
  • 2020

    A Quantitative Proteome Map of the Human Body

    GTEx Consortium, Oct 1 2020, In: Cell. 183, 1, p. 269-283.e19

    Research output: Contribution to journal › Article › peer-review

    Open Access
    149 Scopus citations

  • A vast resource of allelic expression data spanning human tissues

    Castel, S. E., Aguet, F., Mohammadi, P., Aguet, F., Anand, S., Ardlie, K. G., Gabriel, S., Getz, G. A., Graubert, A., Hadley, K., Handsaker, R. E., Huang, K. H., Kashin, S., Li, X., MacArthur, D. G., Meier, S. R., Nedzel, J. L., Nguyen, D. T., Segrè, A. V., Todres, E., & 180 othersAguet, F., Anand, S., Ardlie, K. G., Balliu, B., Barbeira, A. N., Battle, A., Bonazzola, R., Brown, A., Brown, C. D., Castel, S. E., Conrad, D. F., Cotter, D. J., Cox, N., Das, S., De Goede, O. M., Dermitzakis, E. T., Einson, J., Engelhardt, B. E., Eskin, E., Eulalio, T. Y., Ferraro, N. M., Flynn, E. D., Fresard, L., Gamazon, E. R., Garrido-Martín, D., Gay, N. R., Gloudemans, M. J., Graubert, A., Guigó, R., Hadley, K., Hame, A. R., Handsaker, R. E., He, Y., Hoffman, P. J., Hormozdiari, F., Hou, L., Huang, K. H., Im, H. K., Jo, B., Kasela, S., Kashin, S., Kellis, M., Kim-Hellmuth, S., Kwong, A., Lappalainen, T., Li, X., Li, X., Liang, Y., Mangul, S., Meier, S. R., Mohammadi, P., Montgomery, S. B., Muñoz-Aguirre, M., Nachun, D. C., Nedzel, J. L., Nguyen, D. T., Nobel, A. B., Oliva, M., Park, Y. S., Park, Y., Parsana, P., Rao, A. S., Reverter, F., Rouhana, J. M., Sabatti, C., Saha, A., Segrè, A. V., Skol, A. D., Stephens, M., Stranger, B. E., Strober, B. J., Teran, N. A., Todres, E., Viñuela, A., Wang, G., Wen, X., Wright, F., Wucher, V., Zou, Y., Ferreira, P. G., Li, G., Melé, M., Yeger-Lotem, E., Barcus, M. E., Bradbury, D., Krubit, T., McLean, J. A., Qi, L., Robinson, K., Roche, N. V., Smith, A. M., Sobin, L., Tabor, D. E., Undale, A., Bridge, J., Brigham, L. E., Foster, B. A., Gillard, B. M., Hasz, R., Hunter, M., Johns, C., Johnson, M., Karasik, E., Kopen, G., Leinweber, W. F., McDonald, A., Moser, M. T., Myer, K., Ramsey, K. D., Roe, B., Shad, S., Thomas, J. A., Walters, G., Washington, M., Wheeler, J., Jewell, S. D., Rohrer, D. C., Valley, D. R., Davis, D. A., Mash, D. C., Barcus, M. E., Branton, P. A., Sobin, L., Barker, L. K., Gardiner, H. M., Mosavel, M., Siminoff, L. A., Flicek, P., Haeussler, M., Juettemann, T., Kent, W. J., Lee, C. M., Powell, C. C., Rosenbloom, K. R., Ruffier, M., Sheppard, D., Taylor, K., Trevanion, S. J., Zerbino, D. R., Abell, N. S., Akey, J., Chen, L., Demanelis, K., Doherty, J. A., Feinberg, A. P., Hansen, K. D., Hickey, P. F., Hou, L., Jasmine, F., Jiang, L., Kaul, R., Kibriya, M. G., Li, J. B., Li, Q., Lin, S., Linder, S. E., Montgomery, S. B., Oliva, M., Park, Y., Pierce, B. L., Rizzardi, L. F., Skol, A. D., Smith, K. S., Snyder, M., Stamatoyannopoulos, J., Stranger, B. E., Tang, H., Wang, M., Branton, P. A., Carithers, L. J., Guan, P., Koester, S. E., Little, A. R., Moore, H. M., Nierras, C. R., Rao, A. K., Vaught, J. B., Volpi, S., Ardlie, K. G. & Lappalainen, T., Sep 11 2020, In: Genome biology. 21, 1, 234.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Cell type–specific genetic regulation of gene expression across human tissues

    GTEx Consortium, Sep 2020, In: Science. 369, 6509, eaaz8528.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    117 Scopus citations

  • Identifying and Interpreting Apparent Neanderthal Ancestry in African Individuals

    Chen, L., Wolf, A. B., Fu, W., Li, L. & Akey, J. M., Feb 20 2020, In: Cell. 180, 4, p. 677-687.e16

    Research output: Contribution to journal › Article › peer-review

    Open Access
    102 Scopus citations

  • Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans

    Saad-Roy, C. M., Arinaminpathy, N., Wingreen, N. S., Levin, S. A., Akey, J. M. & Grenfell, B. T., Jun 2020, In: PLoS computational biology. 16, 6, e1007892.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • The GTEx Consortium atlas of genetic regulatory effects across human tissues

    The GTEx Consortium, Sep 1 2020, In: Science. 369, 6509, p. 1318-1330 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1239 Scopus citations

  • Transcriptomic signatures across human tissues identify functional rare genetic variation

    TOPMed Lipids Working Group & GTEx Consortium, Sep 11 2020, In: Science. 369, 6509, eaaz5900.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations
  • 2019

    The long walk to African genomics

    Tucci, S. & Akey, J. M., Jun 27 2019, In: Genome biology. 20, 1, 130.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations
  • 2018

    Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture

    Browning, S. R., Browning, B. L., Zhou, Y., Tucci, S. & Akey, J. M., Mar 22 2018, In: Cell. 173, 1, p. 53-61.e9

    Research output: Contribution to journal › Article › peer-review

    Open Access
    185 Scopus citations

  • Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia

    Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., Nelson, B. J., Fu, W., Purnomo, G. A., Sudoyo, H., Eichler, E. E., Barbujani, G., Visscher, P. M., Akey, J. M. & Green, R. E., Aug 3 2018, In: Science. 361, 6401, p. 511-516 6 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Evolution of dnaase i hypersensitive sites in mhc regulatory regions of primates

    Jin, Y., Gittelman, R. M., Lu, Y., Liu, X., Li, M. D., Ling, F. & Akey, J. M., Jun 2018, In: Genetics. 209, 2, p. 579-589 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

    Barbeira, A. N., Dickinson, S. P., Bonazzola, R., Zheng, J., Wheeler, H. E., Torres, J. M., Torstenson, E. S., Shah, K. P., Garcia, T., Edwards, T. L., Stahl, E. A., Huckins, L. M., Aguet, F., Ardlie, K. G., Cummings, B. B., Gelfand, E. T., Getz, G., Hadley, K., Handsaker, R. E., Huang, K. H., & 225 othersKashin, S., Karczewski, K. J., Lek, M., Li, X., MacArthur, D. G., Nedzel, J. L., Nguyen, D. T., Noble, M. S., Segrè, A. V., Trowbridge, C. A., Tukiainen, T., Abell, N. S., Balliu, B., Barshir, R., Basha, O., Battle, A., Bogu, G. K., Brown, A., Brown, C. D., Castel, S. E., Chen, L. S., Chiang, C., Conrad, D. F., Damani, F. N., Davis, J. R., Delaneau, O., Dermitzakis, E. T., Engelhardt Martin, B., Eskin, E., Ferreira, P. G., Frésard, L., Gamazon, E. R., Garrido-Martín, D., Gewirtz, A. D. H., Gliner, G., Gloudemans, M. J., Guigo, R., Hall, I. M., Han, B., He, Y., Hormozdiari, F., Howald, C., Jo, B., Kang, E. Y., Kim, Y., Kim-Hellmuth, S., Lappalainen, T., Li, G., Li, X., Liu, B., Mangul, S., McCarthy, M. I., McDowell, I. C., Mohammadi, P., Monlong, J., Montgomery, S. B., Muñoz-Aguirre, M., Ndungu, A. W., Nobel, A. B., Oliva, M., Ongen, H., Palowitch, J. J., Panousis, N., Papasaikas, P., Park, Y. S., Parsana, P., Payne, A. J., Peterson, C. B., Quan, J., Reverter, F., Sabatti, C., Saha, A., Sammeth, M., Scott, A. J., Shabalin, A. A., Sodaei, R., Stephens, M., Stranger, B. E., Strober, B. J., Sul, J. H., Tsang, E. K., Urbut, S., Van De Bunt, M., Wang, G., Wen, X., Wright, F. A., Xi, H. S., Yeger-Lotem, E., Zappala, Z., Zaugg, J. B., Zhou, Y. H., Akey, J., Bates, D., Chan, J., Claussnitzer, M., Demanelis, K., Diegel, M., Doherty, J. A., Feinberg, A. P., Fernando, M. S., Halow, J., Hansen, K. D., Haugen, E., Hickey, P. F., Hou, L., Jasmine, F., Jian, R., Jiang, L., Johnson, A., Kaul, R., Kellis, M., Kibriya, M. G., Lee, K., Li, J. B., Li, Q., Lin, J., Lin, S., Linder, S., Linke, C., Liu, Y., Maurano, M. T., Molinie, B., Nelson, J., Neri, F. J., Park, Y., Pierce, B. L., Rinaldi, N. J., Rizzardi, L. F., Sandstrom, R., Skol, A., Smith, K. S., Snyder, M. P., Stamatoyannopoulos, J., Tang, H., Wang, L., Wang, M., Van Wittenberghe, N., Wu, F., Zhang, R., Nierras, C. R., Branton, P. A., Carithers, L. J., Guan, P., Moore, H. M., Rao, A., Vaught, J. B., Gould, S. E., Lockart, N. C., Martin, C., Struewing, J. P., Volpi, S., Addington, A. M., Koester, S. E., Little, A. R., Brigham, L. E., Hasz, R., Hunter, M., Johns, C., Johnson, M., Kopen, G., Leinweber, W. F., Lonsdale, J. T., McDonald, A., Mestichelli, B., Myer, K., Roe, B., Salvatore, M., Shad, S., Thomas, J. A., Walters, G., Washington, M., Wheeler, J., Bridge, J., Foster, B. A., Gillard, B. M., Karasik, E., Kumar, R., Miklos, M., Moser, M. T., Jewell, S. D., Montroy, R. G., Rohrer, D. C., Valley, D. R., Davis, D. A., Mash, D. C., Undale, A. H., Smith, A. M., Tabor, D. E., Roche, N. V., McLean, J. A., Vatanian, N., Robinson, K. L., Sobin, L., Barcus, M. E., Valentino, K. M., Qi, L., Hunter, S., Hariharan, P., Singh, S., Um, K. S., Matose, T., Tomaszewski, M. M., Barker, L. K., Mosavel, M., Siminoff, L. A., Traino, H. M., Flicek, P., Juettemann, T., Ruffier, M., Sheppard, D., Taylor, K., Trevanion, S. J., Zerbino, D. R., Craft, B., Goldman, M., Haeussler, M., Kent, W. J., Lee, C. M., Paten, B., Rosenbloom, K. R., Vivian, J., Zhu, J., Nicolae, D. L., Cox, N. J. & Im, H. K., Dec 1 2018, In: Nature communications. 9, 1, 1825.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    452 Scopus citations

  • Massive variation of short tandem repeats with functional consequences across strains of Arabidopsis thaliana

    Press, M. O., McCoy, R. C., Hall, A. N., Akey, J. M. & Queitsch, C., Aug 2018, In: Genome Research. 28, 8, p. 1169-1178 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Rare loss of function variants in candidate genes and risk of colorectal cancer

    NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group, & 15 othersSteering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In: Human Genetics. 137, 10, p. 795-806 12 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations
  • 2017

    Dynamic landscape and regulation of RNA editing in mammals

    GTEx Consortium, Oct 11 2017, In: Nature. 550, 7675, p. 249-254 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    348 Scopus citations

  • Genetic effects on gene expression across human tissues

    GTEx Consortium, Oct 11 2017, In: Nature. 550, 7675, p. 204-213 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2144 Scopus citations

  • Human RECQ Helicase Pathogenic Variants, Population Variation and “Missing” Diseases

    Fu, W., Ligabue, A., Rogers, K. J., Akey, J. M. & Monnat, R. J., Feb 1 2017, In: Human Mutation. 38, 2, p. 193-203 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

    The GTEx Consortium, Nov 2017, In: Genome Research. 27, 11, p. 1859-1871 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome

    Consortia CAAPA Consortium, 2017, In: Scientific reports. 7, 46398.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression

    McCoy, R. C., Wakefield, J. & Akey, J. M., Feb 23 2017, In: Cell. 168, 5, p. 916-927.e12

    Research output: Contribution to journal › Article › peer-review

    Open Access
    90 Scopus citations

  • Improving genetic diagnosis in Mendelian disease with transcriptome sequencing

    Genotype-Tissue Expression Consortium, National Institutes of Health (NIH) Common Fund, iospecimen Collection Source Site-National Disease Research Interchange, Biospecimen Collection Source Site-Roswell Park Cancer Institute, Biospecimen Core Resource-Van Andel Research Institute, Brain Bank Repository-University of Miami, Leidos Biomedical Project Management, Ethical, Legal, and Social Implications Study, Genome Browser Data Integration, and Visualization-European Bioinformatics Institute, Genome Browser Data Integration and Visualization-Genomics Institute, University of California, Santa Cruz:, LDACC-Analysis Working Group (AWG), Funded Statistical Methods groups-AWG, Enhancing GTEx funded Group, NIH/NHGRI, NIH/NCI, NIH/NIMH, NIH/NIDA & Other members of the AWG, Apr 19 2017, In: Science Translational Medicine. 9, 386, eaal5209.

    Research output: Contribution to journal › Article › peer-review

    421 Scopus citations

  • Landscape of X chromosome inactivation across human tissues

    GTEx Consortium, Oct 11 2017, In: Nature. 550, 7675, p. 244-248 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    529 Scopus citations

  • Selection plays the hand it was dealt: Evidence that human adaptation commonly targets standing genetic variation

    McCoy, R. C. & Akey, J. M., Aug 1 2017, In: Genome biology. 18, 1, 139.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • The impact of rare variation on gene expression across tissues

    GTEx Consortium, Oct 11 2017, In: Nature. 550, 7675, p. 239-243 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    142 Scopus citations
  • 2016

    A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

    Mathias, R. A., Taub, M. A., Gignoux, C. R., Fu, W., Musharoff, S., O'Connor, T. D., Vergara, C., Torgerson, D. G., Pino-Yanes, M., Shringarpure, S. S., Huang, L., Rafaels, N., Boorgula, M. P., Johnston, H. R., Ortega, V. E., Levin, A. M., Song, W., Torres, R., Padhukasahasram, B., Eng, C., & 42 othersMejia-Mejia, D. A., Ferguson, T., Qin, Z. S., Scott, A. F., Yazdanbakhsh, M., Wilson, J. G., Marrugo, J., Lange, L. A., Kumar, R., Avila, P. C., Williams, L. K., Watson, H., Ware, L. B., Olopade, C., Olopade, O., Oliveira, R., Ober, C., Nicolae, D. L., Meyers, D., Mayorga, A., Knight-Madden, J., Hartert, T., Hansel, N. N., Foreman, M. G., Ford, J. G., Faruque, M. U., Dunston, G. M., Caraballo, L., Burchard, E. G., Bleecker, E., Araujo, M. I., Herrera-Paz, E. F., Gietzen, K., Grus, W. E., Bamshad, M., Bustamante, C. D., Kenny, E. E., Hernandez, R. D., Beaty, T. H., Ruczinski, I., Akey, J. & Barnes, K. C., Oct 11 2016, In: Nature communications. 7, 12522.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    99 Scopus citations

  • A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets

    Moon, S. & Akey, J. M., Jun 2016, In: Genome Research. 26, 6, p. 834-843 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments

    Gittelman, R. M., Schraiber, J. G., Vernot, B., Mikacenic, C., Wurfel, M. M. & Akey, J. M., Dec 19 2016, In: Current Biology. 26, 24, p. 3375-3382 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    104 Scopus citations

  • Detecting sources of transcriptional heterogeneity in large-scale RNA-seq data sets

    Searle, B. C., Gittelman, R. M., Manor, O. & Akey, J. M., Dec 2016, In: Genetics. 204, 4, p. 1391-1396 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility

    Nuttle, X., Giannuzzi, G., Duyzend, M. H., Schraiber, J. G., Narvaiza, I., Sudmant, P. H., Penn, O., Chiatante, G., Malig, M., Huddleston, J., Benner, C., Camponeschi, F., Ciofi-Baffoni, S., Stessman, H. A. F., Marchetto, M. C. N., Denman, L., Harshman, L., Baker, C., Raja, A., Penewit, K., & 10 othersJanke, N., Joyce Tang, W., Ventura, M., Banci, L., Antonacci, F., Akey, J. M., Amemiya, C. T., Gage, F. H., Reymond, A. & Eichler, E. E., Aug 3 2016, In: Nature. 536, 7615, p. 205-209 5 p.

    Research output: Contribution to journal › Article › peer-review

    82 Scopus citations

  • Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals

    Vernot, B., Tucci, S., Kelso, J., Schraiber, J. G., Wolf, A. B., Gittelman, R. M., Dannemann, M., Grote, S., McCoy, R. C., Norton, H., Scheinfeldt, L. B., Merriwether, D. A., Koki, G., Friedlaender, J. S., Wakefield, J., Pääbo, S. & Akey, J. M., Apr 8 2016, In: Science. 352, 6282, p. 235-239 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    262 Scopus citations

  • Human Diversity in a Cell Surface Receptor that Inhibits Autophagy

    Chaudhary, A., Leite, M., Kulasekara, B. R., Altura, M. A., Ogahara, C., Weiss, E., Fu, W., Blanc, M. P., O'Keeffe, M., Terhorst, C., Akey, J. M. & Miller, S. I., Jul 25 2016, In: Current Biology. 26, 14, p. 1791-1801 11 p.

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Positive selection of the trim family regulatory region in primate genomes

    He, D. D., Lu, Y., Gittelman, R., Jin, Y., Ling, F. & Joshua, A., Oct 12 2016, In: Proceedings of the Royal Society B: Biological Sciences. 283, 1840, 20161602.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Robust Inference of Identity by Descent from Exome-Sequencing Data

    Fu, W., Browning, S. R., Browning, B. L. & Akey, J. M., Nov 3 2016, In: American Journal of Human Genetics. 99, 5, p. 1106-1116 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • The phenotypic legacy of admixture between modern humans and Neandertals

    Simonti, C. N., Vernot, B., Bastarache, L., Bottinger, E., Carrell, D. S., Chisholm, R. L., Crosslin, D. R., Hebbring, S. J., Jarvik, G. P., Kullo, I. J., Li, R., Pathak, J., Ritchie, M. D., Roden, D. M., Verma, S. S., Tromp, G., Prato, J. D., Bush, W. S., Akey, J. M., Denny, J. C., & 1 othersCapra, J. A., Feb 12 2016, In: Science. 351, 6274, p. 737-741 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    186 Scopus citations

  • The time scale of recombination rate evolution in great apes

    Great Ape Genome Project, Apr 1 2016, In: Molecular biology and evolution. 33, 4, p. 928-945 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    60 Scopus citations
  • 2015

    Complex history of admixture between modern humans and neandertals

    Vernot, B. & Akey, J. M., Mar 5 2015, In: American Journal of Human Genetics. 96, 3, p. 448-453 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    88 Scopus citations

  • Comprehensive identification and analysis of human accelerated regulatory DNA

    Gittelman, R. M., Hun, E., Ay, F., Madeoy, J., Pennacchio, L., Noble, W. S., Hawkins, R. D. & Akey, J. M., Sep 1 2015, In: Genome Research. 25, 9, p. 1245-1255 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    66 Scopus citations

  • Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup

    Emery, L. S., Magnaye, K. M., Bigham, A. W., Akey, J. M. & Bamshad, M. J., Feb 5 2015, In: American Journal of Human Genetics. 96, 2, p. 183-193 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • Extreme selective sweeps independently targeted the X chromosomes of the great apes

    Great Ape Genome Diversity Project, May 19 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 20, p. 6413-6418 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    50 Scopus citations

  • Rare variation facilitates inferences of fine-scale population structure in humans

    NHLBI GO Exome Sequencing Project, ESP Population Genetics and Statistical Analysis Working Group, Mar 2015, In: Molecular biology and evolution. 32, 3, p. 653-660 8 p.

    Research output: Contribution to journal › Article › peer-review

    30 Scopus citations
  • 2014

    Characteristics of neutral and deleterious protein-coding variation among individuals and populations

    Fu, W., Gittelman, R. M., Bamshad, M. J. & Akey, J. M., 2014, In: American Journal of Human Genetics. 95, 4, p. 421-436 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    65 Scopus citations

  • Evolution and Genetic Architecture of Chromatin Accessibility and Function in Yeast

    Connelly, C. F., Wakefield, J. & Akey, J. M., Jul 2014, In: PLoS genetics. 10, 7, e1004427.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Global and disease-associated genetic variation in the human Fanconi anemia gene family

    Rogers, K. J., Fu, W., Akey, J. M. & Monnat, R. J., Dec 20 2014, In: Human molecular genetics. 23, 25, p. 6815-6825 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • Heritable variation of mRNA decay rates in yeast

    Andrie, J. M., Wakefield, J. & Akey, J. M., Dec 1 2014, In: Genome Research. 24, 12, p. 2000-2010 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations