• 34788 Citations
  • 93 h-Index
1995 …2024

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2020

Copper-mediated synthesis of drug-like bicyclopentanes

Zhang, X., Smith, R. T., Le, C., McCarver, S. J., Shireman, B. T., Carruthers, N. I. & MacMillan, D. W. C., Apr 9 2020, In : Nature. 580, 7802, p. 220-226 7 p.

Research output: Contribution to journalArticle

2019

A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of α-Chloro Carbonyls with Aryl Halides

Chen, T. Q. & MacMillan, D. W. C., Oct 7 2019, In : Angewandte Chemie - International Edition. 58, 41, p. 14584-14588 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

Kornfilt, D. J. P. & Macmillan, D. W. C., May 1 2019, In : Journal of the American Chemical Society. 141, 17, p. 6853-6858 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Decarboxylative Oxygenation via Photoredox Catalysis

Faraggi, T. M., Li, W. & MacMillan, D. W. C., Jan 1 2019, (Accepted/In press) In : Israel Journal of Chemistry.

Research output: Contribution to journalArticle

Open-Shell Fluorination of Alkyl Bromides: Unexpected Selectivity in a Silyl Radical-Mediated Chain Process

Lovett, G. H., Chen, S., Xue, X. S., Houk, K. N. & MacMillan, D. W. C., Dec 26 2019, In : Journal of the American Chemical Society. 141, 51, p. 20031-20036 6 p.

Research output: Contribution to journalArticle

Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor®

González-Esguevillas, M., Miró, J., Jeffrey, J. L. & MacMillan, D. W. C., Aug 9 2019, In : Tetrahedron. 75, 32, p. 4222-4227 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

Mennen, S. M., Alhambra, C., Allen, C. L., Barberis, M., Berritt, S., Brandt, T. A., Campbell, A. D., Castañón, J., Cherney, A. H., Christensen, M., Damon, D. B., Eugenio De Diego, J., García-Cerrada, S., García-Losada, P., Haro, R., Janey, J., Leitch, D. C., Li, L., Liu, F., Lobben, P. C. & 12 others, Macmillan, D. W. C., Magano, J., McInturff, E., Monfette, S., Post, R. J., Schultz, D., Sitter, B. J., Stevens, J. M., Strambeanu, I. I., Twilton, J., Wang, K. & Zajac, M. A., Jun 21 2019, In : Organic Process Research and Development. 23, 6, p. 1213-1242 30 p.

Research output: Contribution to journalArticle

14 Scopus citations
2018

A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes

Le, C., Chen, T. Q., Liang, T., Zhang, P. & MacMillan, D. W. C., Jun 1 2018, In : Science. 360, 6392, p. 1010-1014 5 p.

Research output: Contribution to journalArticle

87 Scopus citations

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

Bloom, S., Liu, C., Kölmel, D. K., Qiao, J. X., Zhang, Y., Poss, M. A., Ewing, W. R. & Macmillan, D. W. C., Feb 1 2018, In : Nature chemistry. 10, 2, p. 205-211 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Decarboxylative Hydroalkylation of Alkynes

Till, N. A., Smith, R. T. & Macmillan, D. W. C., May 2 2018, In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

22 Scopus citations

Decarboxylative sp 3 C-N coupling via dual copper and photoredox catalysis

Liang, Y., Zhang, X. & MacMillan, D. W. C., Jul 5 2018, In : Nature. 559, 7712, p. 83-88 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Kautzky, J. A., Wang, T., Evans, R. W. & Macmillan, D. W. C., May 30 2018, In : Journal of the American Chemical Society. 140, 21, p. 6522-6526 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Direct arylation of strong aliphatic C–H bonds

Perry, I. B., Brewer, T. F., Sarver, P. J., Schultz, D. M., DiRocco, D. A. & MacMillan, D. W. C., Aug 2 2018, In : Nature. 560, 7716, p. 70-75 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Metallaphotoredox-Catalyzed Cross-Electrophile C sp 3 -C sp 3 Coupling of Aliphatic Bromides

Smith, R. T., Zhang, X., Rincón, J. A., Agejas, J., Mateos, C., Barberis, M., García-Cerrada, S., De Frutos, O. & Macmillan, D. W. C., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17433-17438 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Metallaphotoredox Difluoromethylation of Aryl Bromides

Bacauanu, V., Cardinal, S., Yamauchi, M., Kondo, M., Fernández, D. F., Remy, R. & MacMillan, D. W. C., Sep 17 2018, In : Angewandte Chemie - International Edition. 57, 38, p. 12543-12548 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

Twilton, J., Christensen, M., DiRocco, D. A., Ruck, R. T., Davies, I. W. & MacMillan, D. W. C., May 4 2018, In : Angewandte Chemie - International Edition. 57, 19, p. 5369-5373 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nacsa, E. D. & MacMillan, D. W. C., Mar 7 2018, In : Journal of the American Chemical Society. 140, 9, p. 3322-3330 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis

Kim, T., McCarver, S. J., Lee, C. & MacMillan, D. W. C., Mar 19 2018, In : Angewandte Chemie - International Edition. 57, 13, p. 3488-3492 5 p.

Research output: Contribution to journalArticle

31 Scopus citations
2017

A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions

Le, C. C., Wismer, M. K., Shi, Z. C., Zhang, R., Conway, D. V., Li, G., Vachal, P., Davies, I. W. & MacMillan, D. W. C., Jun 28 2017, In : ACS Central Science. 3, 6, p. 647-653 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Catalyst-controlled oligomerization for the collective synthesis of polypyrroloindoline natural products

Jamison, C. R., Badillo, J. J., Lipshultz, J. M., Comito, R. J. & MacMillan, D. W. C., Dec 1 2017, In : Nature chemistry. 9, 12, p. 1165-1169 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Decarboxylative Peptide Macrocyclization through Photoredox Catalysis

McCarver, S. J., Qiao, J. X., Carpenter, J., Borzilleri, R. M., Poss, M. A., Eastgate, M. D., Miller, M. M. & MacMillan, D. W. C., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 3, p. 728-732 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Direct, enantioselective α-alkylation of aldehydes using simple olefins

Capacci, A. G., Malinowski, J. T., McAlpine, N. J., Kuhne, J. & Macmillan, D. W. C., Jun 26 2017, In : Nature chemistry. 9, 11, p. 1073-1077 5 p.

Research output: Contribution to journalArticle

45 Scopus citations
76 Scopus citations

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Loh, Y. Y., Nagao, K., Hoover, A. J., Hesk, D., Rivera, N. R., Colletti, S. L., Davies, I. W. & MacMillan, D. W. C., Dec 1 2017, In : Science. 358, 6367, p. 1182-1187 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Photosensitized, energy transfer-mediated organometallic catalysis through electronically excited nickel(II)

Welin, E. R., Le, C., Arias-Rotondo, D. M., McCusker, J. K. & MacMillan, D. W. C., Jan 27 2017, In : Science (New York, N.Y.). 355, 6323, p. 380-385 6 p.

Research output: Contribution to journalArticle

139 Scopus citations

Selective sp 3 C-H alkylation via polarity-match-based cross-coupling

Le, C., Liang, Y., Evans, R. W., Li, X. & MacMillan, D. W. C., Jul 6 2017, In : Nature. 547, 7661, p. 79-83 5 p.

Research output: Contribution to journalArticle

135 Scopus citations
2016
78 Scopus citations

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

Corcoran, E. B., Pirnot, M. T., Lin, S., Dreher, S. D., Dirocco, D. A., Davies, I. W., Buchwald, S. L. & Macmillan, D. W. C., Jul 15 2016, In : Science. 353, 6296, p. 279-283 5 p.

Research output: Contribution to journalArticle

174 Scopus citations

Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

Zuo, Z., Cong, H., Li, W., Choi, J., Fu, G. C. & MacMillan, D. W. C., Feb 17 2016, In : Journal of the American Chemical Society. 138, 6, p. 1832-1835 4 p.

Research output: Contribution to journalArticle

223 Scopus citations

Metallaphotoredox-catalysed sp3-sp3 cross-coupling of carboxylic acids with alkyl halides

Johnston, C. P., Smith, R. T., Allmendinger, S. & MacMillan, D. W. C., Aug 17 2016, In : Nature. 536, 7616, p. 322-325 4 p.

Research output: Contribution to journalArticle

184 Scopus citations

Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles

Shaw, M. H., Shurtleff, V. W., Terrett, J. A., Cuthbertson, J. D. & MacMillan, D. W. C., Jun 10 2016, In : Science. 352, 6291, p. 1304-1308 5 p.

Research output: Contribution to journalArticle

213 Scopus citations

Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode

Liu, C., Oblak, E. Z., Vander Wal, M. N., Dilger, A. K., Almstead, D. K. & MacMillan, D. W. C., Mar 2 2016, In : Journal of the American Chemical Society. 138, 7, p. 2134-2137 4 p.

Research output: Contribution to journalArticle

38 Scopus citations
136 Scopus citations
2015

Alcohols as alkylating agents in heteroarene C-H functionalization

Jin, J. & MacMillan, D. W. C., Sep 3 2015, In : Nature. 525, 7567, p. 87-90 4 p.

Research output: Contribution to journalArticle

281 Scopus citations

Decarboxylative fluorination of aliphatic carboxylic acids via photoredox catalysis

Ventre, S., Petronijevic, F. R. & Macmillan, D. W. C., May 6 2015, In : Journal of the American Chemical Society. 137, 17, p. 5654-5657 4 p.

Research output: Contribution to journalArticle

194 Scopus citations
220 Scopus citations

Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes

Welin, E. R., Warkentin, A. A., Conrad, J. C. & MacMillan, D. W. C., Aug 1 2015, In : Angewandte Chemie - International Edition. 54, 33, p. 9668-9672 5 p.

Research output: Contribution to journalArticle

71 Scopus citations
69 Scopus citations

Merging photoredox and nickel catalysis: Decarboxylative cross-coupling of carboxylic acids with vinyl halides

Noble, A., McCarver, S. J. & Macmillan, D. W. C., Jan 21 2015, In : Journal of the American Chemical Society. 137, 2, p. 624-627 4 p.

Research output: Contribution to journalArticle

250 Scopus citations

Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids

Chu, L., Lipshultz, J. M. & Macmillan, D. W. C., Jun 1 2015, In : Angewandte Chemie - International Edition. 54, 27, p. 7929-7933 5 p.

Research output: Contribution to journalArticle

177 Scopus citations

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

Nawrat, C. C., Jamison, C. R., Slutskyy, Y., MacMillan, D. W. C. & Overman, L. E., Sep 9 2015, In : Journal of the American Chemical Society. 137, 35, p. 11270-11273 4 p.

Research output: Contribution to journalArticle

142 Scopus citations

Selective Radical-Radical Cross-Couplings: Design of a Formal β-Mannich Reaction

Jeffrey, J. L., Petronijević, F. R. & Macmillan, D. W. C., Jul 8 2015, In : Journal of the American Chemical Society. 137, 26, p. 8404-8407 4 p.

Research output: Contribution to journalArticle

124 Scopus citations

Switching on elusive organometallic mechanisms with photoredox catalysis

Terrett, J. A., Cuthbertson, J. D., Shurtleff, V. W. & MacMillan, D. W. C., Aug 20 2015, In : Nature. 524, 7565, p. 330-334 5 p.

Research output: Contribution to journalArticle

220 Scopus citations

The direct arylation of allylic sp3 C-H bonds via organic and photoredox catalysis

Cuthbertson, J. D. & MacMillan, D. W. C., Mar 5 2015, In : Nature. 519, 7541, p. 74-77 4 p.

Research output: Contribution to journalArticle

207 Scopus citations
2014
134 Scopus citations

A general and enantioselective approach to pentoses: A rapid synthesis of PSI-6130, the nucleoside core of sofosbuvir

Peifer, M., Berger, R., Shurtleff, V. W., Conrad, J. C. & Macmillan, D. W. C., Apr 23 2014, In : Journal of the American Chemical Society. 136, 16, p. 5900-5903 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

A general strategy for organocatalytic activation of c-h bonds via photoredox catalysis: Direct arylation of benzylic ethers

Qvortrup, K., Rankic, D. A. & MacMillan, D. W. C., Jan 15 2014, In : Journal of the American Chemical Society. 136, 2, p. 626-629 4 p.

Research output: Contribution to journalArticle

148 Scopus citations

Amine α-heteroarylation via photoredox catalysis: A homolytic aromatic substitution pathway

Prier, C. K. & MacMillan, D. W. C., Nov 1 2014, In : Chemical Science. 5, 11, p. 4173-4178 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Carboxylic acids as A traceless activation group for conjugate additions: A three-step synthesis of (±)-pregabalin

Chu, L., Ohta, C., Zuo, Z. & MacMillan, D. W. C., Aug 6 2014, In : Journal of the American Chemical Society. 136, 31, p. 10886-10889 4 p.

Research output: Contribution to journalArticle

244 Scopus citations
254 Scopus citations