• 10981 Citations
  • 45 h-Index
19992020

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Article
2020

Branching morphogenesis

Goodwin, K. & Nelson, C. M., May 2020, In : Development (Cambridge). 147, 10, 184499.

Research output: Contribution to journalArticle

Marangoni flows drive the alignment of fibrillar cell-laden hydrogels

Nerger, B. A., Brun, P. T. & Nelson, C. M., Jun 2020, In : Science Advances. 6, 24, eaaz7748.

Research output: Contribution to journalArticle

Open Access
2019

3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung

Nerger, B. A. & Nelson, C. M., Apr 2019, In : Biomaterials. 198, p. 135-145 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Human organoids: A new dimension in cell biology

Lehmann, R., Lee, C. M., Shugart, E. C., Benedetti, M., Charo, R. A., Gartner, Z., Hogan, B., Knoblich, J., Nelson, C. M. & Wilson, K. M., Jan 1 2019, In : Molecular biology of the cell. 30, 10, p. 1129-1137 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung

Spurlin, J. W., Siedlik, M. J., Nerger, B. A., Pang, M. F., Jayaraman, S., Zhang, R. & Nelson, C. M., Jan 1 2019, In : Development (Cambridge). 146, 16, dev175257.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Microextrusion printing cell-laden networks of type i collagen with patterned fiber alignment and geometry

Nerger, B. A., Brun, P. T. & Nelson, C. M., 2019, In : Soft matter. 15, 28, p. 5728-5738 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Smooth muscle differentiation shapes domain branches during mouse lung development

Goodwin, K., Mao, S., Guyomar, T., Miller, E., Radisky, D. C., Košmrlj, A. & Nelson, C. M., Nov 15 2019, In : Development (Cambridge). 146, 22, dev181172.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

A soft microenvironment protects from failure of Midbody abscission and multinucleation downstream of the EMT-promoting transcription factor snail

Simi, A. K., Anlaş, A. A., Stallings-Mann, M., Zhang, S., Hsia, T., Cichon, M., Radisky, D. C. & Nelson, C. M., May 1 2018, In : Cancer Research. 78, 9, p. 2277-2289 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1

Han, S., Pang, M. F. & Nelson, C. M., Apr 15 2018, In : Journal of cell science. 131, 8, jcs210476.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Cell Division Induces and Switches Coherent Angular Motion within Bounded Cellular Collectives

Siedlik, M. J., Manivannan, S., Kevrekidis, I. G. & Nelson, C. M., Jun 6 2017, In : Biophysical Journal. 112, 11, p. 2419-2427 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dynamics of Tissue-Induced Alignment of Fibrous Extracellular Matrix

Piotrowski-Daspit, A. S., Nerger, B. A., Wolf, A. E., Sundaresan, S. & Nelson, C. M., Aug 8 2017, In : Biophysical Journal. 113, 3, p. 702-713 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

From static to animated: Measuring mechanical forces in tissues

Nelson, C. M., 2017, In : Journal of Cell Biology. 216, 1, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development

Nelson, C. M., Gleghorn, J. P., Pang, M. F., Jaslove, J. M., Goodwin, K., Varner, V. D., Miller, E., Radisky, D. C. & Stone, H. A., Dec 1 2017, In : Development (Cambridge). 144, 23, p. 4328-4335 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Collective migration in tissues

Nelson, C. M., Mar 15 2016, In : Molecular biology of the cell. 27, 6, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Engineering three-dimensional epithelial tissues embedded within extracellular matrix

Piotrowski-Daspit, A. S. & Nelson, C. M., Jul 10 2016, In : Journal of Visualized Experiments. 2016, 113, e54283.

Research output: Contribution to journalArticle

1 Scopus citations

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

Piotrowski-Daspit, A. S., Tien, J. & Nelson, C. M., Mar 2016, In : Integrative Biology (United Kingdom). 8, 3, p. 319-331 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Morphogenesis and morphometric scaling of lung airway development follows phylogeny in chicken, quail, and duck embryos

Tzou, D., Spurlin, J., Pavlovich, A. L., Stewart, C. R., Gleghorn, J. P. & Nelson, C. M., May 26 2016, In : EvoDevo. 7, 1, 12.

Research output: Contribution to journalArticle

6 Scopus citations

On buckling morphogenesis

Nelson, C. M., Feb 1 2016, In : Journal of Biomechanical Engineering. 138, 2, 021005.

Research output: Contribution to journalArticle

25 Scopus citations

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

Pang, M. F., Georgoudaki, A. M., Lambut, L., Johansson, J., Tabor, V., Hagikura, K., Jin, Y., Jansson, M., Alexander, J. S., Nelson, C. M., Jakobsson, L., Betsholtz, C., Sund, M., Karlsson, M. C. I. & Fuxe, J., Feb 11 2016, In : Oncogene. 35, 6, p. 748-760 13 p.

Research output: Contribution to journalArticle

140 Scopus citations

Tissue stiffness and hypoxia modulate the integrin-linked kinase ilk to control breast cancer stem-like cells

Pang, M. F., Siedlik, M. J., Han, S., Stallings-Mann, M., Radisky, D. C. & Nelson, C. M., Sep 15 2016, In : Cancer Research. 76, 18, p. 5277-5287 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2015

Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices

Gjorevski, N., Piotrowski, A. S., Varner, V. D. & Nelson, C. M., Jul 13 2015, In : Scientific reports. 5, 1 p.

Research output: Contribution to journalArticle

58 Scopus citations

Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung

Kim, H. Y., Pang, M. F., Varner, V. D., Kojima, L., Miller, E., Radisky, D. C. & Nelson, C. M., Sep 28 2015, In : Developmental cell. 34, 6, p. 719-726 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Mechanically patterning the embryonic airway epithelium

Varner, V. D., Gleghorn, J. P., Miller, E., Radisky, D. C. & Nelson, C. M., Jul 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. 9230-9235 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Mechanotransduction: Use the force(s)

Paluch, E. K., Nelson, C. M., Biais, N., Fabry, B., Moeller, J., Pruitt, B. L., Wollnik, C., Kudryasheva, G., Rehfeldt, F. & Federle, W., Jul 4 2015, In : BMC Biology. 13, 1, 47.

Research output: Contribution to journalArticle

90 Scopus citations

Mechanotransduction, metastasis and genomic instability

Simi, A. K., Piotrowski, A. S. & Nelson, C. M., Jan 1 2015, In : Cancer Metastasis - Biology and Treatment. 20, p. 139-158 20 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion

Cichon, M. A., Nelson, C. M. & Radisky, D. C., Feb 9 2015, In : Cancer Informatics. 14, p. 1-13 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Three-dimensional traction force microscopy of engineered epithelial tissues

Piotrowski, A. S., Varner, V. D., Gjorevski, N. & Nelson, C. M., Jan 1 2015, In : Methods in Molecular Biology. 1189, p. 191-206 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State

Boghaert, E., Radisky, D. C. & Nelson, C. M., Dec 1 2014, In : PLoS computational biology. 10, 12

Research output: Contribution to journalArticle

17 Scopus citations

Lymphatic function is required prenatally for lung inflation at birth

Jakus, Z., Gleghorn, J. P., Enis, D. R., Sen, A., Chia, S., Liu, X., Rawnsley, D. R., Yang, Y., Hess, P. R., Zou, Z., Yang, J., Guttentag, S. H., Nelson, C. M. & Kahn, M. L., May 2014, In : Journal of Experimental Medicine. 211, 5, p. 815-826 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Microstructured extracellular matrices in tissue engineering and development: An update

Tien, J. & Nelson, C. M., Jul 2014, In : Annals of Biomedical Engineering. 42, 7, p. 1413-1423 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Adipose and mammary epithelial tissue engineering

Zhu, W. & Nelson, C. M., Jul 1 2013, In : Biomatter. 3, 3

Research output: Contribution to journalArticle

10 Scopus citations

Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung

Kim, H. Y., Varner, V. D. & Nelson, C. M., Aug 1 2013, In : Development (Cambridge). 140, 15, p. 3146-3155 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells

Chen, Q. K., Lee, K. A., Radisky, D. C. & Nelson, C. M., Oct 1 2013, In : Differentiation. 86, 3, p. 126-132 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively

Zhu, W. & Nelson, C. M., Jul 15 2013, In : Developmental biology. 379, 2, p. 235-245 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1

Mori, H., Lo, A. T., Inman, J. L., Alcaraz, J., Ghajar, C. M., Mott, J. D., Nelson, C. M., Chen, C. S., Zhang, H., Bascom, J. L., Seiki, M. & Bissell, M. J., 2013, In : Development (Cambridge). 140, 2, p. 343-352 10 p.

Research output: Contribution to journalArticle

67 Scopus citations
2012

Host epithelial geometry regulates breast cancer cell invasiveness

Boghaert, E., Gleghorn, J. P., Lee, K. A., Gjorevski, N., Radisky, D. C. & Nelson, C. M., Nov 27 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19632-19637 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Inhibitory morphogens and monopodial branching of the embryonic chicken lung

Gleghorn, J. P., Kwak, J., Pavlovich, A. L. & Nelson, C. M., May 1 2012, In : Developmental Dynamics. 241, 5, p. 852-862 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues

Gjorevski, N. & Nelson, C. M., Jul 3 2012, In : Biophysical Journal. 103, 1, p. 152-162 11 p.

Research output: Contribution to journalArticle

86 Scopus citations

Matrix compliance and RhoA direct the differentiation of mammary progenitor cells

Lui, C., Lee, K. & Nelson, C. M., Nov 1 2012, In : Biomechanics and Modeling in Mechanobiology. 11, 8, p. 1241-1249 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition

Lee, K. A., Chen, Q. K., Lui, C., Cichon, M. A., Radisky, D. C. & Nelson, C. M., Oct 15 2012, In : Molecular biology of the cell. 23, 20, p. 4097-4108 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Modulation of Invasive Phenotype by Interstitial Pressure-Driven Convection in Aggregates of Human Breast Cancer Cells

Tien, J., Truslow, J. G. & Nelson, C. M., Sep 18 2012, In : PloS one. 7, 9, e45191.

Research output: Contribution to journalArticle

18 Scopus citations

Photoresponsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier

Chung, J. W., Lee, K., Neikirk, C., Nelson, C. M. & Priestley, R. D., Jun 11 2012, In : Small. 8, 11, p. 1693-1700 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

PI3K signaling in the regulation of branching morphogenesis

Zhu, W. & Nelson, C. M., Sep 1 2012, In : BioSystems. 109, 3, p. 403-411 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Symmetry breaking during morphogenesis in the embryo and in engineered tissues

Nelson, C. M., Dec 1 2012, In : AIChE Journal. 58, 12, p. 3608-3613 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Integrated morphodynamic signalling of the mammary gland

Gjorevski, N. & Nelson, C. M., Sep 1 2011, In : Nature Reviews Molecular Cell Biology. 12, 9, p. 581-593 13 p.

Research output: Contribution to journalArticle

119 Scopus citations

Lithographically defined two- and three-dimensional tissue microarrays.

Gomez, E. W. & Nelson, C. M., 2011, In : Methods in molecular biology (Clifton, N.J.). 671, p. 107-116 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture

Pavlovich, A. L., Boghaert, E. & Nelson, C. M., Aug 1 2011, In : Experimental Cell Research. 317, 13, p. 1872-1884 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis

Lee, K., Gjorevski, N., Boghaert, E., Radisky, D. C. & Nelson, C. M., Jul 6 2011, In : EMBO Journal. 30, 13, p. 2662-2674 13 p.

Research output: Contribution to journalArticle

44 Scopus citations