Alexei V. Korennykh

Former affiliation
  • 1573 Citations
  • 18 h-Index
20032020

Research output per year

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Research Output

  • 1573 Citations
  • 18 h-Index
  • 28 Article
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Article
2019

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

Rath, S., Prangley, E., Donovan, J., Demarest, K., Wingreen, N. S., Meir, Y. & Korennykh, A., Sep 19 2019, In : Molecular Cell. 75, 6, p. 1218-1228.e6

Research output: Contribution to journalArticle

5 Scopus citations

Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L

Chitrakar, A., Rath, S., Donovan, J., Demarest, K., Li, Y., Sridhar, R. R., Weiss, S. R., Kotenko, S. V., Wingreen, N. S. & Korennykh, A., Feb 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 6, p. 2103-2111 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)

Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., Aoki, T., Schedl, P., Rabinowitz, J. & Korennykh, A., Dec 1 2019, In : Nature communications. 10, 1, 2367.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Crystal Structure of Human Nocturnin Catalytic Domain

Estrella, M. A., Du, J. & Korennykh, A., Dec 1 2018, In : Scientific reports. 8, 1, 16294.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

Oakes, S. R., Gallego-Ortega, D., Stanford, P. M., Junankar, S., Au, W. W. Y., Kikhtyak, Z., von Korff, A., Sergio, C. M., Law, A. M. K., Castillo, L. E., Allerdice, S. L., Young, A. I. J., Piggin, C., Whittle, B., Bertram, E., Naylor, M. J., Roden, D. L., Donovan, J., Korennykh, A., Goodnow, C. C. & 2 others, O’Bryan, M. K. & Ormandy, C. J., Nov 2017, In : PLoS genetics. 13, 11, e1007072.

Research output: Contribution to journalArticle

4 Scopus citations

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

Donovan, J., Rath, S., Kolet-Mandrikov, D. & Korennykh, A., Nov 2017, In : RNA. 23, 11, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ribonuclease l mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

Li, Y., Banerjee, S., Goldstein, S. A., Dong, B., Gaughan, C., Rath, S., Donovan, J., Korennykh, A., Silverman, R. H. & Weiss, S. R., Mar 31 2017, In : eLife. 6, e25687.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

Mendez, A. S., Alfaro, J., Morales-Soto, M. A., Dar, A. C., McCullagh, E., Gotthardt, K., Li, H., Acosta-Alvear, D., Sidrauski, C., Korennykh, A. V., Bernales, S., Shokat, K. M. & Walter, P., May 19 2015, In : eLife. 4, MAY, e05434.

Research output: Contribution to journalArticle

34 Scopus citations

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome

Rath, S., Donovan, J., Whitney, G., Chitrakar, A., Wang, W. & Korennykh, A., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15916-15921 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3

Donovan, J., Whitney, G., Rath, S. & Korennykh, A., Mar 31 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 13, p. 3949-3954 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1

van Anken, E., Pincus, D., Coyle, S., Aragón, T., Osman, C., Lari, F., Gómez Puerta, S., Korennykh, A. V. & Walter, P., 2014, In : eLife. 3, p. e05031 e05031.

Research output: Contribution to journalArticle

14 Scopus citations

Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response

Han, Y., Donovan, J., Rath, S., Whitney, G., Chitrakar, A. & Korennykh, A., 2014, In : Science. 343, 6176, p. 1244-1248 5 p.

Research output: Contribution to journalArticle

69 Scopus citations
2013
81 Scopus citations
2012

Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes

Han, Y., Whitney, G., Donovan, J. & Korennykh, A. V., Oct 25 2012, In : Cell Reports. 2, 4, p. 902-913 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structural basis of the unfolded protein response

Korennykh, A. & Walter, P., Dec 3 2012, In : Annual review of cell and developmental biology. 28, p. 251-277 27 p.

Research output: Contribution to journalArticle

115 Scopus citations
2011

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

Korennykh, A. V., Egea, P. F., Korostelev, A. A., Finer-Moore, J., Stroud, R. M., Zhang, C., Shokat, K. M. & Walter, P., Jul 6 2011, In : BMC Biology. 9, 48.

Research output: Contribution to journalArticle

33 Scopus citations

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

Rubio, C., Pincus, D., Korennykh, A., Schuck, S., El-Samad, H. & Walter, P., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 171-184 14 p.

Research output: Contribution to journalArticle

96 Scopus citations

Structural and functional basis for RNA cleavage by Ire1

Korennykh, A. V., Korostelev, A. A., Egea, P. F., Finer-Moore, J., Stroud, R. M., Zhang, C., Shokat, K. M. & Walter, P., Jul 6 2011, In : BMC Biology. 9, 47.

Research output: Contribution to journalArticle

35 Scopus citations

The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues

Plantinga, M. J., Korennykh, A. V., Piccirilli, J. A. & Correll, C. C., Apr 12 2011, In : Biochemistry. 50, 14, p. 3004-3013 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

Li, H., Korennykh, A. V., Behrman, S. L. & Walter, P., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16113-16118 6 p.

Research output: Contribution to journalArticle

195 Scopus citations
2009

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

Aragón, T., Van Anken, E., Pincus, D., Serafimova, I. M., Korennykh, A. V., Rubio, C. A. & Walter, P., Feb 5 2009, In : Nature. 457, 7230, p. 736-740 5 p.

Research output: Contribution to journalArticle

210 Scopus citations

The unfolded protein response signals through high-order assembly of Ire1

Korennykh, A. V., Egea, P. F., Korostelev, A. A., Finer-Moore, J., Zhang, C., Shokat, K. M., Stroud, R. M. & Walter, P., Feb 5 2009, In : Nature. 457, 7230, p. 687-693 7 p.

Research output: Contribution to journalArticle

382 Scopus citations
2008

Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate

Plantinga, M. J., Korennykh, A. V., Piccirilli, J. A. & Correll, C. C., Aug 26 2008, In : Biochemistry. 47, 34, p. 8912-8918 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins

Korennykh, A. V., Correll, C. C. & Piccirilli, J. A., Sep 2007, In : RNA. 13, 9, p. 1391-1396 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin

Korennykh, A. V., Plantinga, M. J., Correll, C. C. & Piccirilli, J. A., Nov 6 2007, In : Biochemistry. 46, 44, p. 12744-12756 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins

Korennykh, A. V., Piccirilli, J. A. & Correll, C. C., May 14 2006, In : Nature Structural and Molecular Biology. 13, 5, p. 436-443 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
2004

Use of high acyl donor concentrations leads to penicillin acylase inactivation in the course of peptide synthesis

Shcherbakova, T. A., Korennykh, A. V., Langen, L. M. V., Sheldon, R. A. & Švedas, V. K., Oct 15 2004, In : Journal of Molecular Catalysis B: Enzymatic. 31, 1-3, p. 63-65 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
2003

Penicillin acylase-catalyzed peptide synthesis in aqueous medium: A chemo-enzymatic route to stereoisomerically pure diketopiperazines

Khimiuk, A. Y., Korennykh, A. V., Van Langen, L. M., Van Rantwijk, F., Sheldon, R. A. & Švedas, V. K., Oct 17 2003, In : Tetrahedron Asymmetry. 14, 20, p. 3123-3128 6 p.

Research output: Contribution to journalArticle

23 Scopus citations